Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Aug 1:4:19.
doi: 10.1186/s40813-018-0092-7. eCollection 2018.

Clinical efficacy of two vaccination strategies against Mycoplasma hyopneumoniae in a pig herd suffering from respiratory disease

Vojislav Cvjetković  1 , Sabine Sipos  2 , Imre Szabó  3 , Wolfgang Sipos  4
Affiliations

Clinical efficacy of two vaccination strategies against Mycoplasma hyopneumoniae in a pig herd suffering from respiratory disease

Vojislav Cvjetković et al. Porcine Health Manag. .

Abstract

Background: A randomised field trial was conducted on an Austrian farrow-to-finish farm for one year to compare the efficacy of two commercial Mycoplasma hyopneumoniae vaccines. 585 piglets either received the one-shot formulation in group 1 (Hyogen®, 23.9 days of age) or a two-shot vaccine (Stellamune® Mycoplasma, 4.3 and 24.0 days of age) in group 2. Assessment of vaccine efficacy was evaluated by regression analyses through cough monitoring from nursery to slaughter, average daily weight gain from inclusion to slaughter, antibiotic treatment rate (ATR), mortality rate, and lung lesion scoring at slaughter.

Results: In general, coughing was more frequent during late nursery and finishing. No significant differences were found in the coughing index (0.02 vs 0.03) and mean average daily weight gain (560 vs 550 g) between the two groups. ATR was higher in group 2 (3.8 vs 9.6%). At the slaughterhouse check, significant differences in the prevalence of bronchopneumonia (62.9 vs 71.2%) could be found. Extension of lung lesions was also significantly lower in group 1 in terms of enzootic pneumonia (EP) values (p = 0.000, z = - 4.269). There were no significant differences in the rate of scarred lungs (20.0 vs 24.0%) or those affected by dorsocaudal pleurisy (36.8 vs 34.3%).

Conclusions: This trial demonstrated that Hyogen® was superior to Stellamune® Mycoplasma in reducing (I) the prevalence of bronchopneumonic lungs and those affected by cranioventral pleurisy, (II) the extension and severity of EP-like lung lesions, and (III) the rate of antibiotically treated animals against respiratory disease.

Keywords: Lung health; Mycoplasma hyopneumoniae; One-shot vaccine; Randomised field trial; Two-shot-vaccine.

PubMed Disclaimer

Conflict of interest statement

The present trial did not include any invasive procedures or treatments to the pigs, therefore animal ethics committee approval was not required. An owner consent was provided by the farmer prior to starting the study.All authors agreed to the publication of the present manuscript.First and third author of this research article are employees from the company sponsor.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Comparison of EP-value distributions between vaccination group 1 (n = 280) and vaccination group 2 (n = 271)
See this image and copyright information in PMC

References

    1. Hsu T, Minion FC. Identification of the cilium binding epitope of the mycoplasma hyopneumoniae P97 Adhesin. Infect Immun. 1998;66:4762–4766. - PMC - PubMed
    1. Adams C, Pitzer J, Minion FC. In vivo expression analysis of the P97 and P102 paralog families of Mycoplasma hyopneumoniae. Infect Immun. 2005;73:7784–7787. doi: 10.1128/IAI.73.11.7784-7787.2005. - DOI - PMC - PubMed
    1. Burnett TA, Dinkla K, Rohde M, Chhatwal GS, Uphoff C, Srivastava M, Cordwell SJ, Geary S, Liao X, Minion FC, Walker MJ, Djordjevic SP. P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae: defined domains of P159 bind heparin and promote adherence to eukaryote cells. Mol Microbiol. 2006;60(3):669–686. doi: 10.1111/j.1365-2958.2006.05139.x. - DOI - PubMed
    1. Ferrarini MG, Siquiera FM, Mucha SG, Palama TL, Jobard E, Elena-Hermann B, Vasconcelos ATR, Tardy F, Schrank IS, Zaha A, Sagot MF. Insights on the virulence of swine respiratory tract mycoplasmas through genome-scale metabolic modeling. BMC Genomics. 2016;17:353. doi: 10.1186/s12864-016-2644-z. - DOI - PMC - PubMed
    1. Thacker EL, Minion FC. Mycoplasmosis. In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW, editors. Diseases of Swine. 10. Chichester: John Wiley & Sons Ltd; 2012. pp. 779–786.

LinkOut - more resources