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. 2018 Jul 31:6:e5287.
doi: 10.7717/peerj.5287. eCollection 2018.

Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study

I-Shen Huang  1   2   3   4 , Sung-En Huang  5 , Wei-Tang Kao  6   7 , Cheng-Yen Chiang  8 , To Chang  9 , Cheng-I Lin  10 , Alex T Lin  2   3   4 , Chih-Chieh Lin  3 , Yu-Hua Fan  2   3 , Hsiao-Jen Chung  2   3   4
Affiliations

Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study

I-Shen Huang et al. PeerJ. .

Abstract

Background: The purpose of this study was to investigate the relationship between chronic periodontitis (CP) and upper urinary tract stone (UUTS) in Taiwan by using a population-based data set.

Methods: A total of 16,292 CP patients and 48,876 randomly-selected controls without chronic periodontitis were selected from the National research database and studied retrospectively. Subjects selected have not been diagnosed with UUTS previously. These subjects were prospectively followed for at least eight years. Cox regression models were used to explore the connection between risk factors and the development of UUTS.

Results: The CP patients have a greater chance of developing UUTS compared to controls (1761/16292, 10.8% vs. 4775/48876, 9.8%, p-values < 0.001). Conditioned logistic regression suggested CP increases the risk of UUTS development (HR 1.14, 95% CI [1.08-1.20], p < 0.001). After respective adjustment for age, gender, hypertension and diabetes, results showed that CP still increases the risk of developing UUTS (HR 1.14, 95% CI [1.08-1.20], p < 0.001).

Conclusion: By using a population-based database with a minimum eight 8 follow-up of CP in Taiwan, we discovered patients with CP are more likely to develop UUTS.

Keywords: Chronic periodontitis; Upper urinary tract stone; Urolithiasis.

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Conflict of interest statement

The authors declare there are no competing interests.

Figures

Figure 1
Figure 1. Probability free of upper urinary tract stone (UUTS) for periodontitis and non-periodontitis patients.
See this image and copyright information in PMC

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