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Editorial
. 2018 Aug;40(4):361-364.
doi: 10.1007/s11357-018-0036-9. Epub 2018 Aug 6.

How healthy is the healthspan concept?

Matt Kaeberlein  1
Affiliations
Editorial

How healthy is the healthspan concept?

Matt Kaeberlein. Geroscience. 2018 Aug.
No abstract available

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Figures

Fig. 1
Fig. 1
Dramatic increase in use of the word “healthspan” in biomedical literature. The cumulative number of Pubmed indexed articles annotated with “healthspan” or “health span” in the title or abstract is shown by year. A total of 929 articles were returned. Date of search: July 15, 2018
Fig. 2
Fig. 2
Hypothetical “healthspan metric” curves. Idealized example of data that could be obtained for two individuals who are assessed for a standardized healthspan metric (defined on a 10-point scale) annually over their entire lives. Individual no. 1 (black filled circles) illustrates the potential for declining health followed by recovery around age 36 and again around age 57. Individual no. 2 (red open circles) illustrates someone who is exceptionally healthy until near the very end of life. By calculating the area under each curve, a single “healthspan metric” can be obtained. Individual no. 1 has a lifetime healthspan value of 610 compared to individual no. 2 with a lifetime healthspan value of 796. Both individuals have a lifespan of 87 years
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References

    1. An JY, Quarles EK, Mekvanich S, Kang A, Liu A, Santos D, Miller RA, Rabinovitch PS, Cox TC, Kaeberlein M. Rapamycin treatment attenuates age-associated periodontitis in mice. Geroscience. 2017;39:457–463. doi: 10.1007/s11357-017-9994-6. - DOI - PMC - PubMed
    1. Bansal A, Zhu LJ, Yen K, Tissenbaum HA. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A. 2015;112:E277–E286. doi: 10.1073/pnas.1412192112. - DOI - PMC - PubMed
    1. Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. eLife. 2016;5:e16351. doi: 10.7554/eLife.16351. - DOI - PMC - PubMed
    1. Burch JB, Augustine AD, Frieden LA, Hadley E, Howcroft TK, Johnson R, Khalsa PS, Kohanski RA, Li XL, Macchiarini F, Niederehe G, Oh YS, Pawlyk AC, Rodriguez H, Rowland JH, Shen GL, Sierra F, Wise BC. Advances in geroscience: impact on healthspan and chronic disease. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl 1):S1–S3. doi: 10.1093/gerona/glu041. - DOI - PMC - PubMed
    1. Ewald CY, Castillo-Quan JI, Blackwell TK. Untangling longevity, Dauer, and healthspan in Caenorhabditis elegans insulin/IGF-1-signalling. Gerontology. 2018;64:96–104. doi: 10.1159/000480504. - DOI - PMC - PubMed

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