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Book

Calciphylaxis

Scott G. Westphal  1 , Troy Plumb  1
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Calciphylaxis

Scott G. Westphal et al.
Free Books & Documents

Excerpt

Calciphylaxis is a rare but devastating disorder most commonly observed in patients with end-stage renal disease, although it does occasionally develop in patients with acute renal failure, normal renal function, or earlier stages of chronic kidney disease (non-uremic calciphylaxis). Also known as calcific uremic arteriolopathy, it is characterized by painful skin lesions caused by cutaneous arteriolar calcification leading to tissue ischemia and infarction. Calciphylaxis is associated with substantial morbidity due to severe pain, nonhealing wounds, and frequent hospitalizations. It is a highly fatal condition with 1-year mortality rates greater than 50%, most often due to sepsis.

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Conflict of interest statement

Disclosure: Scott Westphal declares no relevant financial relationships with ineligible companies.

Disclosure: Troy Plumb declares no relevant financial relationships with ineligible companies.

References

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    1. Jovanovich A, Chonchol M. Calcific Uremic Arteriolopathy Revisited. J Am Soc Nephrol. 2016 Nov;27(11):3233-3235. - PMC - PubMed
    1. Brandenburg VM, Kramann R, Rothe H, Kaesler N, Korbiel J, Specht P, Schmitz S, Krüger T, Floege J, Ketteler M. Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry. Nephrol Dial Transplant. 2017 Jan 01;32(1):126-132. - PubMed
    1. Nigwekar SU, Solid CA, Ankers E, Malhotra R, Eggert W, Turchin A, Thadhani RI, Herzog CA. Quantifying a rare disease in administrative data: the example of calciphylaxis. J Gen Intern Med. 2014 Aug;29 Suppl 3(Suppl 3):S724-31. - PMC - PubMed
    1. Price PA, Williamson MK, Nguyen TM, Than TN. Serum levels of the fetuin-mineral complex correlate with artery calcification in the rat. J Biol Chem. 2004 Jan 16;279(3):1594-600. - PubMed

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