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Review
. 2018 Aug 7;25(1):61.
doi: 10.1186/s12929-018-0463-z.

Genetic influence alters the brain synchronism in perception and timing

Victor Marinho  1   2   3 , Thomaz Oliveira  4   5 , Juliete Bandeira  4 , Giovanny R Pinto  5   6 , Anderson Gomes  5 , Valéria Lima  5 , Francisco Magalhães  4   6 , Kaline Rocha  4   6 , Carla Ayres  4 , Valécia Carvalho  4   6 , Bruna Velasques  7 , Pedro Ribeiro  7 , Marco Orsini  8 , Victor Hugo Bastos  9 , Daya Gupta  10 , Silmar Teixeira  4   6
Affiliations
Review

Genetic influence alters the brain synchronism in perception and timing

Victor Marinho et al. J Biomed Sci. .

Abstract

Background: Studies at the molecular level aim to integrate genetic and neurobiological data to provide an increasingly detailed understanding of phenotypes related to the ability in time perception.

Main text: This study suggests that the polymorphisms genetic SLC6A4 5-HTTLPR, 5HTR2A T102C, DRD2/ANKK1-Taq1A, SLC6A3 3'-UTR VNTR, COMT Val158Met, CLOCK genes and GABRB2 A/C as modification factor at neurochemical levels associated with several neurofunctional aspects, modifying the circadian rhythm and built-in cognitive functions in the timing. We conducted a literature review with 102 studies that met inclusion criteria to synthesize findings on genetic polymorphisms and their influence on the timing.

Conclusion: The findings suggest an association of genetic polymorphisms on behavioral aspects related in timing. However, order to confirm the paradigm of association in the timing as a function of the molecular level, still need to be addressed future research.

Keywords: Circadian rhythm; Dopamine; GABA; Genetic polymorphisms; Serotonin; Time perception.

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Conflict of interest statement

Authors’ information

VM, TO, AG and VL are researchers of the Neuro-innovation Technology & Brain Mapping Laboratory, Federal University of Piauí, Parnaíba, Brazil, and Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaíba, Brazil.

JB, KR, FM, VC, and CA are researchers of the Neuro-innovation Technology & Brain Mapping Laboratory, Federal University of Piauí, Parnaíba, Brazil.

GRP is a professor and mentor in the Master and PhD programs at Federal University of Piauí. He is a head of the Genetics and Molecular Biology Laboratory.

BV and PR are professors at the Federal University of Rio de Janeiro, and Brain Mapping and Sensory Motor Integration Laboratory, Institute of Psychiatry of Federal University of Rio de Janeiro, Brazil.

MO is professor of Master’s Program in Local Development and Health Sciences Applied Program on University Center Augusto Motta - UNISUAM, Rio de Janeiro, Brazil.

DG is an adjunct professor of Biology at Camden County College, Blackwood, New Jersey, USA.

VHB is professor at the Federal University of Piauí. Mentor in the Master program at Federal University of Piauí. He is a head of the Brain Mapping and Functionality Laboratory.

ST is professor at the Federal University of Piauí. Mentor in the Master and PhD. programs at Federal University of Piauí. He is a head of the Neuro-innovation Technology & Brain Mapping Laboratory.

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Modular connection among the parietal cortex, prefrontal cortex and striatum. The proposed inbuilt modular clock in the prefrontal cortex is responsible for synchronizing the time perception. Genetic polymorphisms modulate the functions of the parietal and prefrontal cortex; reduced interference in the role of striatal oscillations in the representation of time intervals in the brain. Thus, decreases the efficiency in coding the time intervals
See this image and copyright information in PMC

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