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Review
. 2018 Aug 7;15(8):1679.
doi: 10.3390/ijerph15081679.

Rebuilding the Gut Microbiota Ecosystem

Antonella Gagliardi  1 , Valentina Totino  2 , Fatima Cacciotti  3 , Valerio Iebba  4 , Bruna Neroni  5 , Giulia Bonfiglio  6 , Maria Trancassini  7 , Claudio Passariello  8 , Fabrizio Pantanella  9 , Serena Schippa  10
Affiliations
Review

Rebuilding the Gut Microbiota Ecosystem

Antonella Gagliardi et al. Int J Environ Res Public Health. .

Abstract

A microbial ecosystem in which bacteria no longer live in a mutualistic association is called dysbiotic. Gut microbiota dysbiosis is a condition related with the pathogenesis of intestinal illnesses (irritable bowel syndrome, celiac disease, and inflammatory bowel disease) and extra-intestinal illnesses (obesity, metabolic disorder, cardiovascular syndrome, allergy, and asthma). Dysbiosis status has been related to various important pathologies, and many therapeutic strategies aimed at restoring the balance of the intestinal ecosystem have been implemented. These strategies include the administration of probiotics, prebiotics, and synbiotics; phage therapy; fecal transplantation; bacterial consortium transplantation; and a still poorly investigated approach based on predatory bacteria. This review discusses the various aspects of these strategies to counteract intestinal dysbiosis.

Keywords: dysbiosis; eubiosis; gut microbiota; therapeutic strategy.

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Conflict of interest statement

The authors declare no conflicts of interest.

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