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. 2018 Jul 17;6(7):1244-1247.
doi: 10.3889/oamjms.2018.260. eCollection 2018 Jul 20.

Assessment of the Role of the Anti-Mullerian Hormone, Luteinizing Hormone/Follicle Stimulating Hormone Ratio in the Diagnosis of Polycystic Ovary Syndrome in Sudanese Women

Hafza Tola  1 , Mohammed Abbas  2 , Elsir Abu Alhassan  3 , Nassr Eldin Shrif  1 , Mohammed Rida  3
Affiliations

Assessment of the Role of the Anti-Mullerian Hormone, Luteinizing Hormone/Follicle Stimulating Hormone Ratio in the Diagnosis of Polycystic Ovary Syndrome in Sudanese Women

Hafza Tola et al. Open Access Maced J Med Sci. .

Abstract

Background: The diagnosis of polycystic ovary syndrome (PCOS) is not an easy procedure, as the signs and symptoms are heterogeneous and of undefined aetiology.

Aim: This study is aimed to evaluate serum anti-Mullerian hormone (AMH) level and luteinizing hormone (LH)/folic stimulating hormone (FSH) ratio in women with PCOS in Sudan and to assess the diagnostic efficiency for the diagnosis of PCOS.

Methods: In a case-control study, Serum AMH, LH, FSH was measured in the early follicular phase from Sudanese patients (N = 230) with PCOS and100 controls. The LH/FSH ratio was calculated, and its diagnostic power was evaluated by receiver operating characteristic curves.

Results: The means of serum AMH, serum LH level and LH/FSH ratio of the test, were significantly increased in the test group compared to the control group (P-value < 0.000). The AMH sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) were found to be 83%, 99%, 99%, and 72% respectively. Serum AMH was considered adequate measures for the diagnosis of PCOS; its level showed an area under the ROC curve of 0.98 (95% confidence, P-value < 0.000). The best compromise between 98% specificity and 90% sensitivity was obtained with a cut-off value of 3.3 ng/mL for PCOS diagnosis. There was no correlation between age, body mass index (BMI) and AMH level in the test group.

Conclusions: The Serum AMH level and LH/FSH ratio were higher in patients than in control. However AMH level has better discriminative power and good diagnostic potency for the diagnosis of the PCOS among Sudanese women.

Keywords: Anti-Müllerian hormone; Follicle Stimulating Hormone; Luteinizing Hormone; Ovulation; Polycystic Ovary Syndrome; Sudanese women.

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Figures

Figure 1
Figure 1
ROC curves for the detection of PCOS AMH and LH/FSH ratio
Figure 2
Figure 2
A scatter plot shows the correlation between the level of AMH and age in test (P-value = 0.488)
Figure 3
Figure 3
A scatter plot shows the correlation between the level of AMH and BMI in the test group (P-value = 0.492)
See this image and copyright information in PMC

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