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Case Reports
. 2018 Jun 5;10(6):e2735.
doi: 10.7759/cureus.2735.

Radiographic Diagnosis of a Central Giant Cell Granuloma Using Advanced Imaging: Cone Beam Computed Tomography

Ahmed Z Abdelkarim  1 , Shaimaa M Abu El Sadat  2 , Milda Chmieliauskaite  3 , Ali Z Syed  3
Affiliations
Case Reports

Radiographic Diagnosis of a Central Giant Cell Granuloma Using Advanced Imaging: Cone Beam Computed Tomography

Ahmed Z Abdelkarim et al. Cureus. .

Abstract

Central giant cell granuloma (CGCG) is a benign non-neoplastic, proliferative intraosseous lesion of the jaw with an unknown etiology often diagnosed during the first two decades of life. The true nature of this lesion is controversial and remains elusive. Here, we report a case of central giant cell granuloma, diagnosed using cone-beam computed tomography (CBCT). A 21-year-old female presented to the clinic complaining of a painless swelling involving the right side of the mandible that had started one year previously. A CBCT scan revealed a well-defined, multilocular radiolucent lesion on the right side of the mandible extending from the molar region to the ramus with wispy septations. Wispy septations and undulating borders are some of the characteristic radiographic features of a central giant cell granuloma. The patient underwent an excisional biopsy. The biopsy revealed multinucleated giant cells in a fibrous stroma confirming our radiographic diagnosis of a central giant cell lesion.

Keywords: advanced imaging; cbct; central giant cell granuloma; cone-beam computed tomography; diagnostic imaging; image interpretation; mandible.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Volume rendering showing medial extension of the lesion (yellow circles)
Figure 2
Figure 2. Sagittal images showing undulating border (yellow arrows)
Figure 3
Figure 3. Thin, wispy septations are shown using yellow arrows
See this image and copyright information in PMC

References

    1. Central giant cell granuloma of the posterior maxilla: a case report. Ebrahimi H, Yazdani J, Pourshahidi S, et al. J Dent Res Dent Clin Dent Prospects. 2008;2:71–75. - PMC - PubMed
    1. Fibro-osseous lesions vs. central giant cell granuloma: a hybrid lesion. Geetha N, Pattathan RK, Shivakumar H, Upasi A. Ann Maxillofac Surg. 2011;1:70–73. - PMC - PubMed
    1. A central giant cell granuloma in posterior part of maxilla - A case report. Garg P, Jain J, De N, Chatterjee K. Int J Surg Case Rep. 2017;30:222–225. - PMC - PubMed
    1. Clinical and radiological features of central giant-cell lesions of the jaw. de Lange J, van den Akker HP. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:464–470. - PubMed
    1. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. Liu B, Yu SF, Li TJ. J Oral Pathol Med. 2003;32:367–375. - PubMed

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