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. 2018 Nov;27(11):2935-2944.
doi: 10.1007/s11136-018-1958-5. Epub 2018 Aug 7.

Evaluating the PROMIS-29 v2.0 for use among older adults with multiple chronic conditions

Adam J Rose  1   2 , Elizabeth Bayliss  3   4 , Wenjing Huang  5 , Lesley Baseman  6 , Emily Butcher  6 , Rosa-Elena García  5 , Maria Orlando Edelen  6
Affiliations

Evaluating the PROMIS-29 v2.0 for use among older adults with multiple chronic conditions

Adam J Rose et al. Qual Life Res. 2018 Nov.

Abstract

Purpose: The Patient-Reported Outcomes Measurement Information System 29-item profile (PROMIS-29 v2.0), which measures health-related quality of life (HRQoL), has had limited evaluation among older adults (age 65+) with multiple chronic conditions. Our purpose was to establish convergent validity for PROMIS-29 in this population.

Methods: We collected the PROMIS-29 v2.0 and the Veterans RAND 36 (VR-36) for 1359 primary care patients aged 65 + with at least 2 of 13 chronic conditions, oversampling those aged 80+. We conducted multiple analyses to examine score differences across subgroups, differential item functioning (DIF), and comparisons of PROMIS-29 v2.0 and VR-36 scores.

Results: The mean age was 80.7, and all patients had at least 2 of 13 chronic conditions. Older age, female sex, Hispanic ethnicity, and more chronic conditions were associated with worse physical health scores (PHS) and mental health scores (MHS) on the PROMIS-29 v2.0-findings which are in the expected direction. None of the 700 pairs of items met criteria for DIF. PHS and MHS were highly intercorrelated (r = 0.74, p < 0.001 for this and all other findings). PHS was more highly correlated with the VR-36 Physical Component Score (PCS) than the Mental Component Score (MCS) (r = 0.85 and 0.32, respectively), while MHS was highly correlated with both (r = 0.70 and 0.64, respectively).

Conclusions: PROMIS-29 v2.0 demonstrates expected bivariate relationships with key person-level characteristics and does not show DIF. PROMIS-29 v2.0 scores are highly correlated with VR-36 scores. These results provide support for the validity of PROMIS-29 v2.0 as a measure of HRQoL among older adults with multiple chronic conditions.

Keywords: Chronic disease; Comorbidity; Elderly; Geriatrics; PROMIS; Quality of life.

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Conflict of interest statement

Disclosures: The authors have no conflicts of interest to report.

Conflict of Interest: The authors declare that they have no relevant conflicts of interest.

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