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Comment
. 2018 Aug 7;28(2):183-184.
doi: 10.1016/j.cmet.2018.07.008.

Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Batya Isaacson  1 , Ofer Mandelboim  2
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Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Batya Isaacson et al. Cell Metab. .
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Abstract

Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype.

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