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Case Reports
. 2018 Aug;11(8):1196-1201.
doi: 10.1016/j.jcmg.2018.07.005.

Research to Practice: Assessment of Left Ventricular Global Longitudinal Strain for Surveillance of Cancer Chemotherapeutic-Related Cardiac Dysfunction

Hong Yang  1 , Leah Wright  1 , Tomoko Negishi  1 , Kazuaki Negishi  1 , Jennifer Liu  2 , Thomas H Marwick  3
Affiliations
Case Reports

Research to Practice: Assessment of Left Ventricular Global Longitudinal Strain for Surveillance of Cancer Chemotherapeutic-Related Cardiac Dysfunction

Hong Yang et al. JACC Cardiovasc Imaging. 2018 Aug.
No abstract available

Keywords: cardiac dysfunction; cardiotoxicity; left ventricle strain.

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Figures

Figure 1.
Figure 1.. Elderly female with HER-positive breast cancer, no other risk factors, treated with trastuzumab after anthracycline.
Baseline GLS with automated function imaging (AFI, GE Medical Systems) was 21%. After her third monthly dose of trastuzumab, GLS decreased to 16%. Video is provided to illustrate the steps below (Video 1-3,on-line).
Figure 2.
Figure 2.. 62 year-old female with obesity and hypertension, and HER-positive breast cancer, scheduled to receive anthracycline followed by trastuzumab.
Baseline GLS, processed with AutoStrain (Image Arena, TomTec Imaging System) is low normal (−17%). Video is provided to illustrate the steps below (video 4, on line).
Figure 3.
Figure 3.. 74 year-old male with hypertension and type 2 diabetes mellitus, treated with anthracycline for non-Hodgkins lymphoma.
Baseline GLS measurement is undertaken with automated function imaging (Automated Cardiac Motion Quantification [aCMQ], Philips), as illustrated in video 5, 6 on-line
Figure 4.
Figure 4.. 72 year-old male with type 2 diabetes.
Baseline GLS with velocity vector imaging (Siemens) is gathered in preparation for exposure to anthracycline. Video is provided to illustrate the steps below (F3, on line).
See this image and copyright information in PMC

References

    1. Plana JC, Galderisi M, Barac A et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2014;27:911–39. - PubMed
    1. Farsalinos KE, Daraban AM, Unlu S, Thomas JD, Badano LP, Voigt JU. Head-to-Head Comparison of Global Longitudinal Strain Measurements among Nine Different Vendors: The EACVI/ASE Inter-Vendor Comparison Study. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2015;28:1171–1181, e2. - PubMed
    1. Negishi K, Negishi T, Kurosawa K et al. Practical guidance in echocardiographic assessment of global longitudinal strain. JACC Cardiovascular imaging 2015;8:489–92. - PubMed

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