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. 1986 Apr;72(4):318-9.
doi: 10.1007/BF00290956.

Molecular characterization of HbH disease in the Cuban population

G Martinez, R Ferreira, A Hernandez, A Di Rienzo, L Felicetti, B Colombo

Molecular characterization of HbH disease in the Cuban population

G Martinez et al. Hum Genet. 1986 Apr.

Abstract

Molecular characterization of the alpha-thalassemia mutations present in nine HbH subjects from Cuba was achieved by digestion with Bam HI, Bgl II, and Apa I and hybridization with alpha- and zeta-specific probes. The results show that the molecular basis of the genetic defect is quite homogeneous, all the subjects carrying the - alpha 3.7 type I/--SEA genotype. Variations are observed in the size of the zeta polymorphic fragments.

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