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Comment
. 2018 Aug 9;132(6):554-555.
doi: 10.1182/blood-2018-06-857508.

Detailing the genomic landscape of myeloma

P Leif Bergsagel  1 , W Michael Kuehl  2
Affiliations
Comment

Detailing the genomic landscape of myeloma

P Leif Bergsagel et al. Blood. .

Abstract

An integrated genomic analysis presented by Walker et al in this issue of Blood confirms that the primary genetic event partially determines the pattern of secondary genetic events in untreated multiple myeloma (MM).

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
MM can be divided into nonoverlapping molecular subtypes, shown in circles, based on the primary genetic event, identified by black text. These appear to partially determine the profile of secondary genetics events, summarized in red text. Clustering of the copy number abnormalities identifies novel clusters with convergent evolution, such as cluster 7, identifying patients with a poor prognosis.
See this image and copyright information in PMC

Comment on

  • Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.
    Walker BA, Mavrommatis K, Wardell CP, Ashby TC, Bauer M, Davies FE, Rosenthal A, Wang H, Qu P, Hoering A, Samur M, Towfic F, Ortiz M, Flynt E, Yu Z, Yang Z, Rozelle D, Obenauer J, Trotter M, Auclair D, Keats J, Bolli N, Fulciniti M, Szalat R, Moreau P, Durie B, Stewart AK, Goldschmidt H, Raab MS, Einsele H, Sonneveld P, San Miguel J, Lonial S, Jackson GH, Anderson KC, Avet-Loiseau H, Munshi N, Thakurta A, Morgan GJ. Walker BA, et al. Blood. 2018 Aug 9;132(6):587-597. doi: 10.1182/blood-2018-03-840132. Epub 2018 Jun 8. Blood. 2018. PMID: 29884741 Free PMC article.

References

    1. Walker BA, Mavrommatis K, Wardell CP, et al. . Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma. Blood. 2018;132(6):587-597. - PMC - PubMed
    1. Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy J Jr. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood. 2005;106(1):296-303. - PMC - PubMed
    1. Morgan GJ, Walker BA, Davies FE. The genetic architecture of multiple myeloma. Nat Rev Cancer. 2012;12(5):335-348. - PubMed
    1. Kuehl WM, Bergsagel PL. Molecular pathogenesis of multiple myeloma and its premalignant precursor. J Clin Invest. 2012;122(10):3456-3463. - PMC - PubMed
    1. Bolli N, Biancon G, Moarii M, et al. . Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups [published online ahead of print 22 May 2018]. Leukemia. doi:10.1038/leu.2017.344. - PMC - PubMed

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