. 2018 Aug 9;9(1):3166.

doi: 10.1038/s41467-018-05427-7.

Identification of nine new susceptibility loci for endometrial cancer

Tracy A O'Mara¹, Dylan M Glubb², Frederic Amant³, Daniela Annibali³, Katie Ashton^{4

5

6}, John Attia^{4

7}, Paul L Auer^{8

9}, Matthias W Beckmann¹⁰, Amanda Black¹¹, Manjeet K Bolla¹², Hiltrud Brauch^{13

14

15}, Hermann Brenner^{15

16

17}, Louise Brinton¹¹, Daniel D Buchanan^{18

19

20

21}, Barbara Burwinkel^{22

23}, Jenny Chang-Claude^{24

25}, Stephen J Chanock¹¹, Chu Chen²⁶, Maxine M Chen²⁷, Timothy H T Cheng²⁸, Christine L Clarke²⁹, Mark Clendenning^{18

21}, Linda S Cook^{30

31}, Fergus J Couch³², Angela Cox³³, Marta Crous-Bous^{27

34}, Kamila Czene³⁵, Felix Day³⁶, Joe Dennis¹², Jeroen Depreeuw^{3

37

38}, Jennifer Anne Doherty³⁹, Thilo Dörk⁴⁰, Sean C Dowdy⁴¹, Matthias Dürst⁴², Arif B Ekici⁴³, Peter A Fasching^{10

44}, Brooke L Fridley⁴⁵, Christine M Friedenreich³¹, Lin Fritschi⁴⁶, Jenny Fung⁴⁷, Montserrat García-Closas^{11

48}, Mia M Gaudet⁴⁹, Graham G Giles^{19

50

51}, Ellen L Goode⁵², Maggie Gorman²⁸, Christopher A Haiman⁵³, Per Hall^{35

54}, Susan E Hankison^{34

55}, Catherine S Healey⁵⁶, Alexander Hein¹⁰, Peter Hillemanns⁴⁰, Shirley Hodgson⁵⁷, Erling A Hoivik^{58

59}, Elizabeth G Holliday^{4

7}, John L Hopper¹⁹, David J Hunter^{27

60}, Angela Jones²⁸, Camilla Krakstad^{58

59}, Vessela N Kristensen^{61

62

63}, Diether Lambrechts^{38

64}, Loic Le Marchand⁶⁵, Xiaolin Liang⁶⁶, Annika Lindblom⁶⁷, Jolanta Lissowska⁶⁸, Jirong Long⁶⁹, Lingeng Lu⁷⁰, Anthony M Magliocco⁷¹, Lynn Martin⁷², Mark McEvoy⁷, Alfons Meindl⁷³, Kyriaki Michailidou^{12

74}, Roger L Milne^{19

50}, Miriam Mints⁷⁵, Grant W Montgomery^{2

47}, Rami Nassir⁷⁶, Håkan Olsson⁷⁷, Irene Orlow⁶⁶, Geoffrey Otton⁷⁸, Claire Palles²⁸, John R B Perry³⁶, Julian Peto⁷⁹, Loreall Pooler⁵³, Jennifer Prescott³⁴, Tony Proietto⁷⁸, Timothy R Rebbeck^{80

81}, Harvey A Risch⁷⁰, Peter A W Rogers⁸², Matthias Rübner⁸³, Ingo Runnebaum⁴², Carlotta Sacerdote^{84

85}, Gloria E Sarto⁸⁶, Fredrick Schumacher⁸⁷, Rodney J Scott^{4

5

6

88}, V Wendy Setiawan⁵³, Mitul Shah⁵⁶, Xin Sheng⁵³, Xiao-Ou Shu⁶⁹, Melissa C Southey^{18

89}, Anthony J Swerdlow^{90

91}, Emma Tham^{67

92}, Jone Trovik^{58

59}, Constance Turman²⁷, Jonathan P Tyrer⁵⁶, Celine Vachon⁹³, David VanDen Berg⁵³, Adriaan Vanderstichele⁹⁴, Zhaoming Wang¹¹, Penelope M Webb⁹⁵, Nicolas Wentzensen¹¹, Henrica M J Werner^{58

59}, Stacey J Winham⁹⁶, Alicja Wolk⁹⁷, Lucy Xia⁵³, Yong-Bing Xiang⁹⁸, Hannah P Yang¹¹, Herbert Yu⁶⁵, Wei Zheng⁶⁹, Paul D P Pharoah^{12

56}, Alison M Dunning⁵⁶, Peter Kraft^{27

60}, Immaculata De Vivo^{27

34}, Ian Tomlinson^{28

72}, Douglas F Easton^{12

56}, Amanda B Spurdle⁹⁹, Deborah J Thompson¹⁰⁰

Affiliations

¹ Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia. Tracy.OMara@qimrberghofer.edu.au.
² Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia.
³ Department of Obstetrics and Gynecology, University Hospitals KU Leuven, University of Leuven, Division of Gynecologic Oncology, Leuven, 3000, Belgium.
⁴ John Hunter Hospital, Hunter Medical Research Institute, Newcastle, 2305, NSW, Australia.
⁵ University of Newcastle, Centre for Information Based Medicine, Callaghan, 2308, NSW, Australia.
⁶ University of Newcastle, Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, Callaghan, 2308, NSW, Australia.
⁷ University of Newcastle, Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Callaghan, 2308, NSW, Australia.
⁸ Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, 98109, WA, USA.
⁹ University of Wisconsin-Milwaukee, Zilber School of Public Health, Milwaukee, 53205, WI, USA.
¹⁰ Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN, Erlangen, 91054, Germany.
¹¹ National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, 20892, MD, USA.
¹² Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.
¹³ Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, 70376, Germany.
¹⁴ University of Tübingen, Tübingen, 72074, Germany.
¹⁵ German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, 69120, Germany.
¹⁶ Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
¹⁷ Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, 69120, Germany.
¹⁸ Department of Clinical Pathology, The University of Melbourne, Melbourne, 3010, VIC, Australia.
¹⁹ The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, 3010, VIC, Australia.
²⁰ Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, 3010, VIC, Australia.
²¹ Victorian Comprehensive Cancer Centre, University of Melbourne Centre for Cancer Research, Parkville, 3010, VIC, Australia.
²² Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, 69120, Germany.
²³ Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
²⁴ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
²⁵ University Medical Center Hamburg-Eppendorf, Cancer Epidemiology, University Cancer Center Hamburg (UCCH), Hamburg, 20246, Germany.
²⁶ Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, 98109, WA, USA.
²⁷ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
²⁸ University of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, Oxford, OX3 7BN, UK.
²⁹ University of Sydney, Westmead Institute for Medical Research, Sydney, 2145, NSW, Australia.
³⁰ University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, 87131, NM, USA.
³¹ Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, T2N 4N2, AB, Canada.
³² Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 55905, MN, USA.
³³ Department of Oncology and Metabolism, University of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA), Sheffield, S10 2TN, UK.
³⁴ Department of Medicine, Harvard Medical School, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, 02115, MA, USA.
³⁵ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 65, Sweden.
³⁶ University of Cambridge, MRC Epidemiology Unit, School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
³⁷ VIB, Vesalius Research Center, Leuven, 3000, Belgium.
³⁸ Department of Human Genetics, University of Leuven, Laboratory for Translational Genetics, Leuven, 3000, Belgium.
³⁹ Cancer Research Huntsman Cancer Institute Department of Population Health Sciences, University of Utah, Salt Lake City, 84112, UT, USA.
⁴⁰ Gynaecology Research Unit, Hannover Medical School, Hannover, 30625, Germany.
⁴¹ Department of Obstetrics and Gynecology, Mayo Clinic, Division of Gynecologic Oncology, Rochester, 55905, MN, USA.
⁴² Department of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, 07743, Germany.
⁴³ Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Institute of Human Genetics, University Hospital Erlangen, Erlangen, 91054, Germany.
⁴⁴ Department of Medicine, University of California at Los Angeles, David Geffen School of Medicine, Division of Hematology and Oncology, Los Angeles, 90095, CA, USA.
⁴⁵ Department of Biostatistics, Kansas University Medical Center, Kansas City, 66160, KS, USA.
⁴⁶ Curtin University, School of Public Health, Perth, 6102, WA, Australia.
⁴⁷ University of Queensland, Institute for Molecular Bioscience, Brisbane, 4072, QLD, Australia.
⁴⁸ Institute of Cancer Research, Division of Genetics and Epidemiology, London, SM2 5NG, UK.
⁴⁹ American Cancer Society, Epidemiology Research Program, Atlanta, 30303, GA, USA.
⁵⁰ Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, 3004, VIC, Australia.
⁵¹ Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, VIC, Australia.
⁵² Department of Health Science Research, Mayo Clinic, Division of Epidemiology, Rochester, 55905, MN, USA.
⁵³ Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, 90033, CA, USA.
⁵⁴ Department of Oncology, South General Hospital, Stockholm, 118 83, Sweden.
⁵⁵ Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, Amherst, 01003, MA, USA.
⁵⁶ Department of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.
⁵⁷ Department of Clinical Genetics, St George's, University of London, London, SW17 0RE, UK.
⁵⁸ Department of Clinical Science, University of Bergen, Centre for Cancer Biomarkers, Bergen, 5020, Norway.
⁵⁹ Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, 5021, Norway.
⁶⁰ Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
⁶¹ Department of Cancer Genetics, Oslo University Hospital, Radiumhospitalet, Institute for Cancer Research, Oslo, 0379, Norway.
⁶² University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, 0450, Norway.
⁶³ Department of Clinical Molecular Biology, University of Oslo, Oslo University Hospital, Oslo, 0450, Norway.
⁶⁴ VIB, VIB Center for Cancer Biology, Leuven, 3001, Belgium.
⁶⁵ Epidemiology Program, University of Hawaii Cancer Center, Honolulu, 96813, HI, USA.
⁶⁶ Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, 10065, NY, USA.
⁶⁷ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 171 76, Sweden.
⁶⁸ Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center-Oncology Institute, Warsaw, 02-034, Poland.
⁶⁹ Department of Medicine, Vanderbilt University School of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, 37232, TN, USA.
⁷⁰ Chronic Disease Epidemiology, Yale School of Public Health, New Haven, 06510, CT, USA.
⁷¹ Department of Anatomic Pathology, Moffitt Cancer Center and Research Institute, Tampa, 33612, FL, USA.
⁷² University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, B15 2TT, UK.
⁷³ Department of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich, Munich, 80336, Germany.
⁷⁴ Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
⁷⁵ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden.
⁷⁶ Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, 95817, CA, USA.
⁷⁷ Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, 222 42, Sweden.
⁷⁸ University of Newcastle, School of Medicine and Public Health, Callaghan, 2308, NSW, Australia.
⁷⁹ Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
⁸⁰ Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
⁸¹ Dana-Farber Cancer Institute, Boston, 02115, MA, USA.
⁸² Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Gynaecology Research Centre, Parkville, 3052, VIC, Australia.
⁸³ Department of Gynaecology and Obstetrics, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Erlangen, 91054, Germany.
⁸⁴ Center for Cancer Prevention (CPO-Peimonte), Turin, 10126, Italy.
⁸⁵ Human Genetics Foundation (HuGeF), Turino, 10126, Italy.
⁸⁶ Department of Obstetrics and Gynecology, University of Wisconsin, School of Medicine and Public Health, Madison, 53715, WI, USA.
⁸⁷ Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, 44106, OH, USA.
⁸⁸ John Hunter Hospital, Division of Molecular Medicine, Pathology North, Newcastle, 2308, NSW, Australia.
⁸⁹ Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, 3168, VIC, Australia.
⁹⁰ Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK.
⁹¹ Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK.
⁹² Karolinska Institutet, Clinical Genetics, Stockholm, 171 76, Sweden.
⁹³ Department of Health Sciences Research, Mayo Clinic, Rochester, 55905, MN, USA.
⁹⁴ Department of Obstetrics and Gynaecology, University Hospitals Leuven, Division of Gynecologic Oncology, Leuven Cancer Institute, Leuven, 3000, Belgium.
⁹⁵ Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia.
⁹⁶ Department of Health Science Research, Mayo Clinic, Division of Biomedical Statistics and Informatics, Rochester, 55905, MN, USA.
⁹⁷ Department of Environmental Medicine, Karolinska Institutet, Division of Nutritional Epidemiology, Stockholm, 171 77, Sweden.
⁹⁸ Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, State Key Laboratory of Oncogene and Related Genes, Shanghai, China.
⁹⁹ Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia. Amanda.Spurdle@qimrberghofer.edu.au.
¹⁰⁰ Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK. djt25@medschl.cam.ac.uk.

PMID: 30093612
PMCID: PMC6085317
DOI: 10.1038/s41467-018-05427-7

Identification of nine new susceptibility loci for endometrial cancer

Tracy A O'Mara et al. Nat Commun. 2018.

. 2018 Aug 9;9(1):3166.

doi: 10.1038/s41467-018-05427-7.

Authors

Affiliations

¹ Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia. Tracy.OMara@qimrberghofer.edu.au.
² Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia.
³ Department of Obstetrics and Gynecology, University Hospitals KU Leuven, University of Leuven, Division of Gynecologic Oncology, Leuven, 3000, Belgium.
⁴ John Hunter Hospital, Hunter Medical Research Institute, Newcastle, 2305, NSW, Australia.
⁵ University of Newcastle, Centre for Information Based Medicine, Callaghan, 2308, NSW, Australia.
⁶ University of Newcastle, Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, Callaghan, 2308, NSW, Australia.
⁷ University of Newcastle, Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Callaghan, 2308, NSW, Australia.
⁸ Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, 98109, WA, USA.
⁹ University of Wisconsin-Milwaukee, Zilber School of Public Health, Milwaukee, 53205, WI, USA.
¹⁰ Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN, Erlangen, 91054, Germany.
¹¹ National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, 20892, MD, USA.
¹² Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.
¹³ Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, 70376, Germany.
¹⁴ University of Tübingen, Tübingen, 72074, Germany.
¹⁵ German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, 69120, Germany.
¹⁶ Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
¹⁷ Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, 69120, Germany.
¹⁸ Department of Clinical Pathology, The University of Melbourne, Melbourne, 3010, VIC, Australia.
¹⁹ The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, 3010, VIC, Australia.
²⁰ Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, 3010, VIC, Australia.
²¹ Victorian Comprehensive Cancer Centre, University of Melbourne Centre for Cancer Research, Parkville, 3010, VIC, Australia.
²² Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, 69120, Germany.
²³ Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
²⁴ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
²⁵ University Medical Center Hamburg-Eppendorf, Cancer Epidemiology, University Cancer Center Hamburg (UCCH), Hamburg, 20246, Germany.
²⁶ Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, 98109, WA, USA.
²⁷ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
²⁸ University of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, Oxford, OX3 7BN, UK.
²⁹ University of Sydney, Westmead Institute for Medical Research, Sydney, 2145, NSW, Australia.
³⁰ University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, 87131, NM, USA.
³¹ Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, T2N 4N2, AB, Canada.
³² Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 55905, MN, USA.
³³ Department of Oncology and Metabolism, University of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA), Sheffield, S10 2TN, UK.
³⁴ Department of Medicine, Harvard Medical School, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, 02115, MA, USA.
³⁵ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 65, Sweden.
³⁶ University of Cambridge, MRC Epidemiology Unit, School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
³⁷ VIB, Vesalius Research Center, Leuven, 3000, Belgium.
³⁸ Department of Human Genetics, University of Leuven, Laboratory for Translational Genetics, Leuven, 3000, Belgium.
³⁹ Cancer Research Huntsman Cancer Institute Department of Population Health Sciences, University of Utah, Salt Lake City, 84112, UT, USA.
⁴⁰ Gynaecology Research Unit, Hannover Medical School, Hannover, 30625, Germany.
⁴¹ Department of Obstetrics and Gynecology, Mayo Clinic, Division of Gynecologic Oncology, Rochester, 55905, MN, USA.
⁴² Department of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, 07743, Germany.
⁴³ Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Institute of Human Genetics, University Hospital Erlangen, Erlangen, 91054, Germany.
⁴⁴ Department of Medicine, University of California at Los Angeles, David Geffen School of Medicine, Division of Hematology and Oncology, Los Angeles, 90095, CA, USA.
⁴⁵ Department of Biostatistics, Kansas University Medical Center, Kansas City, 66160, KS, USA.
⁴⁶ Curtin University, School of Public Health, Perth, 6102, WA, Australia.
⁴⁷ University of Queensland, Institute for Molecular Bioscience, Brisbane, 4072, QLD, Australia.
⁴⁸ Institute of Cancer Research, Division of Genetics and Epidemiology, London, SM2 5NG, UK.
⁴⁹ American Cancer Society, Epidemiology Research Program, Atlanta, 30303, GA, USA.
⁵⁰ Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, 3004, VIC, Australia.
⁵¹ Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, VIC, Australia.
⁵² Department of Health Science Research, Mayo Clinic, Division of Epidemiology, Rochester, 55905, MN, USA.
⁵³ Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, 90033, CA, USA.
⁵⁴ Department of Oncology, South General Hospital, Stockholm, 118 83, Sweden.
⁵⁵ Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, Amherst, 01003, MA, USA.
⁵⁶ Department of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.
⁵⁷ Department of Clinical Genetics, St George's, University of London, London, SW17 0RE, UK.
⁵⁸ Department of Clinical Science, University of Bergen, Centre for Cancer Biomarkers, Bergen, 5020, Norway.
⁵⁹ Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, 5021, Norway.
⁶⁰ Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
⁶¹ Department of Cancer Genetics, Oslo University Hospital, Radiumhospitalet, Institute for Cancer Research, Oslo, 0379, Norway.
⁶² University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, 0450, Norway.
⁶³ Department of Clinical Molecular Biology, University of Oslo, Oslo University Hospital, Oslo, 0450, Norway.
⁶⁴ VIB, VIB Center for Cancer Biology, Leuven, 3001, Belgium.
⁶⁵ Epidemiology Program, University of Hawaii Cancer Center, Honolulu, 96813, HI, USA.
⁶⁶ Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, 10065, NY, USA.
⁶⁷ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 171 76, Sweden.
⁶⁸ Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center-Oncology Institute, Warsaw, 02-034, Poland.
⁶⁹ Department of Medicine, Vanderbilt University School of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, 37232, TN, USA.
⁷⁰ Chronic Disease Epidemiology, Yale School of Public Health, New Haven, 06510, CT, USA.
⁷¹ Department of Anatomic Pathology, Moffitt Cancer Center and Research Institute, Tampa, 33612, FL, USA.
⁷² University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, B15 2TT, UK.
⁷³ Department of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich, Munich, 80336, Germany.
⁷⁴ Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
⁷⁵ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden.
⁷⁶ Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, 95817, CA, USA.
⁷⁷ Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, 222 42, Sweden.
⁷⁸ University of Newcastle, School of Medicine and Public Health, Callaghan, 2308, NSW, Australia.
⁷⁹ Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
⁸⁰ Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
⁸¹ Dana-Farber Cancer Institute, Boston, 02115, MA, USA.
⁸² Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Gynaecology Research Centre, Parkville, 3052, VIC, Australia.
⁸³ Department of Gynaecology and Obstetrics, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Erlangen, 91054, Germany.
⁸⁴ Center for Cancer Prevention (CPO-Peimonte), Turin, 10126, Italy.
⁸⁵ Human Genetics Foundation (HuGeF), Turino, 10126, Italy.
⁸⁶ Department of Obstetrics and Gynecology, University of Wisconsin, School of Medicine and Public Health, Madison, 53715, WI, USA.
⁸⁷ Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, 44106, OH, USA.
⁸⁸ John Hunter Hospital, Division of Molecular Medicine, Pathology North, Newcastle, 2308, NSW, Australia.
⁸⁹ Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, 3168, VIC, Australia.
⁹⁰ Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK.
⁹¹ Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK.
⁹² Karolinska Institutet, Clinical Genetics, Stockholm, 171 76, Sweden.
⁹³ Department of Health Sciences Research, Mayo Clinic, Rochester, 55905, MN, USA.
⁹⁴ Department of Obstetrics and Gynaecology, University Hospitals Leuven, Division of Gynecologic Oncology, Leuven Cancer Institute, Leuven, 3000, Belgium.
⁹⁵ Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia.
⁹⁶ Department of Health Science Research, Mayo Clinic, Division of Biomedical Statistics and Informatics, Rochester, 55905, MN, USA.
⁹⁷ Department of Environmental Medicine, Karolinska Institutet, Division of Nutritional Epidemiology, Stockholm, 171 77, Sweden.
⁹⁸ Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, State Key Laboratory of Oncogene and Related Genes, Shanghai, China.
⁹⁹ Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia. Amanda.Spurdle@qimrberghofer.edu.au.
¹⁰⁰ Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK. djt25@medschl.cam.ac.uk.

PMID: 30093612
PMCID: PMC6085317
DOI: 10.1038/s41467-018-05427-7

Abstract

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1**
Manhattan plot of the results of the endometrial cancer meta-analysis of 12,906 cases and 108,979 controls. Genetic variants are plotted according to chromosome and position (x axis) and statistical significance (y axis). The red line marks the 5 × 10⁻⁸ GWAS significance threshold. a Endometrial cancer (all histologies). b Endometrial cancer (all histologies) excluding variants within 500 kb of previously published endometrial cancer variants. c Endometrioid histology endometrial cancer excluding variants within 500 kb of previously published endometrial cancer variants. d Non-endometrioid histology endometrial cancer

**Fig. 2**
Regional association plots for the nine novel endometrial cancer loci. –log₁₀(p) from the fixed-effects meta-analysis is on the left y axis, recombination rate (cM/Mb) is on the right y axis (plotted as blue lines). The color of the circles shows the level of linkage disequilibrium between each variant and the most significantly associated variant (purple diamond) (r² from the 1000 Genomes 2014 EUR reference panel—see key). Genes in the region are shown beneath each plot. a 1p34.3, b 2p16.1, c 9p21.3, d 11p13, e 12p12.1, f 12q24.11, g 12q24.21, h 17q11.2, i 17q21.32

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References

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1. Johnatty SE, et al. Family history of cancer predicts endometrial cancer risk independently of Lynch syndrome: implications for genetic counselling. Gynecol. Oncol. 2017;147:381–387. doi: 10.1016/j.ygyno.2017.08.011. - DOI - PubMed
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Identification of nine new susceptibility loci for endometrial cancer

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Identification of nine new susceptibility loci for endometrial cancer

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