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. 1986 Jan;23(1):155-9.
doi: 10.1128/jcm.23.1.155-159.1986.

Complex-specific immunoglobulin M antibody patterns in humans infected with alphaviruses

C H Calisher, A O el-Kafrawi, M I Al-Deen Mahmud, A P Travassos da Rosa, C R Bartz, M Brummer-Korvenkontio, S Haksohusodo, W Suharyono

Complex-specific immunoglobulin M antibody patterns in humans infected with alphaviruses

C H Calisher et al. J Clin Microbiol. 1986 Jan.

Abstract

Sera from humans with serologically confirmed eastern equine encephalitis, western equine encephalitis, Pogosta (Ockelbo), Mayaro, Ross River, and chikungunya virus infections were tested by immunoglobulin M (IgM) antibody capture enzyme immunoassay. Diagnostically useful IgM antibody titers were detected, and selected sera with high IgM antibody titers were tested for IgM antibody with nine heterologous alphaviruses. The results provide evidence for the complex specificity of IgM antibody and indicate the usefulness of this test in both individual cases and epidemic situations.

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