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. 1986 Feb;23(2):381-2.
doi: 10.1128/jcm.23.2.381-382.1986.

Effect of using heat-inactivated serum with the Abbott human T-cell lymphotropic virus type III antibody test

D L Jungkind, S A DiRenzo, S J Young

Effect of using heat-inactivated serum with the Abbott human T-cell lymphotropic virus type III antibody test

D L Jungkind et al. J Clin Microbiol. 1986 Feb.

Abstract

The Abbott enzyme immunoassay (Abbott Laboratories, North Chicago, Ill.) for human T-cell lymphotropic virus type III (HTLV-III) antibody was evaluated to determine the effect of using heat-inactivated (56 degrees C for 30 min) serum as the sample. Each of 58 nonreactive serum samples gave a higher A492 value when tested after heat inactivation. Ten of the samples became reactive after heating. Heat-inactivated serum should not be used in the current Abbott HTLV-III antibody test, because this can cause false-positive results.

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