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Review
. 2018 Sep:129:40-43.
doi: 10.1016/j.critrevonc.2018.06.006. Epub 2018 Jun 18.

Immune check-point in cervical cancer

F De Felice  1 , C Marchetti  2 , I Palaia  3 , R Ostuni  3 , L Muzii  3 , V Tombolini  1 , P Benedetti Panici  3
Affiliations
Review

Immune check-point in cervical cancer

F De Felice et al. Crit Rev Oncol Hematol. 2018 Sep.

Abstract

Despite different treatment strategies, locally advanced cervical cancer (CC) persists as one of the most incurable cancers among women worldwide. In fact, this setting of patients are at high risk of persistent and recurrent disease. In recent years, researches have investigated immune check-point inhibitors in hopes of determining improved response to therapy with prolongation of survival. We reviewed the published literature and conference proceedings and presented pivotal trials supporting immune check-point inhibitors use in the treatment of CC.

Keywords: CTLA-4; Cervical cancer; Immune check-point; Immunotherapy; Ipilimumab; Nivolumab; PD-1; Pembrolizumab.

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