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Practice Guideline
. 2018 Aug 10:362:k3284.
doi: 10.1136/bmj.k3284.

Corticosteroid therapy for sepsis: a clinical practice guideline

Francois Lamontagne  1   2 , Bram Rochwerg  3   4 , Lyubov Lytvyn  4 , Gordon H Guyatt  4 , Morten Hylander Møller  5 , Djillali Annane  6 , Michelle E Kho  7 , Neill K J Adhikari  8   9 , Flavia Machado  10   11 , Per O Vandvik  12   13 , Peter Dodek  14 , Rebecca Leboeuf  15 , Matthias Briel  4   16 , Madiha Hashmi  17 , Julie Camsooksai  18 , Manu Shankar-Hari  19   20 , Mahder Kinfe Baraki  21 , Karie Fugate  22 , Shunjie Chua  23 , Christophe Marti  24 , Dian Cohen  25 , Edouard Botton  26 , Thomas Agoritsas  4   27 , Reed A C Siemieniuk  28
Affiliations
Practice Guideline

Corticosteroid therapy for sepsis: a clinical practice guideline

Francois Lamontagne et al. BMJ. .
No abstract available

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Conflict of interest statement

Competing interests: All authors have completed the BMJ Rapid Recommendations interests disclosure form, and a detailed description of all disclosures is reported in appendix 2 on bmj.com. As with all BMJ Rapid Recommendations, the executive team and The BMJ judged that no panel member had any financial conflict of interest. Professional and academic interests are minimised as much as possible, while maintaining necessary expertise on the panel to make fully informed decisions.

Figures

Fig 2
Fig 2
Characteristics of patients and trials included in systematic review of the use of corticosteroids for treating sepsis CAP = community acquired pneumonia. ARDS = acute respiratory distress syndrome.
Fig 3
Fig 3
Practical issues about use of corticosteroids for treatment of sepsis
See this image and copyright information in PMC

References

    1. Venkatesh B, Finfer S, Cohen J, et al. ADRENAL Trial Investigators and the Australian-New Zealand Intensive Care Society Clinical Trials Group Adjunctive glucocorticoid therapy in patients with septic shock. N Engl J Med 2018;378:797-808. 10.1056/NEJMoa1705835 - DOI - PubMed
    1. Annane D, Renault A, Brun-Buisson C, et al. CRICS-TRIGGERSEP Network Hydrocortisone plus fludrocortisone for adults with septic shock. N Engl J Med 2018;378:809-18. 10.1056/NEJMoa1705716 - DOI - PubMed
    1. Rochwerg B, Oczkowski SJ, Siemieniuk RAC, et al. Corticosteroids in sepsis: an updated systematic review and meta-analysis. Crit Care Med 2018. 10.1097/CCM.0000000000003262 - DOI - PubMed
    1. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016;315:801-10. 10.1001/jama.2016.0287 - DOI - PMC - PubMed
    1. Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996;22:707-10. 10.1007/BF01709751 - DOI - PubMed

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