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. 2018 Aug 10;8(8):77.
doi: 10.1038/s41408-018-0114-3.

RBFOX2 and alternative splicing in B-cell lymphoma

Hilmar Quentmeier  1 , Claudia Pommerenke  2 , Stephan H Bernhart  3 , Wilhelm G Dirks  2 , Vivien Hauer  2 , Steve Hoffmann  4 , Stefan Nagel  2 , Reiner Siebert  5 , Cord C Uphoff  2 , Margarete Zaborski  2 , Hans G Drexler  2 ; ICGC MMML-Seq Consortium
Affiliations

RBFOX2 and alternative splicing in B-cell lymphoma

Hilmar Quentmeier et al. Blood Cancer J. .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. RBFOX2 and RBFOX2 targets in B-NHL cell lines.
a Heatmap of RNAseq data showing expression of individual MALT1 exons and corresponding joining sequences (red boxes: exon 7 and exon 7 joining sequences). Expression of full-length MALT1 correlates with expression of RBFOX2. b Expression array analysis (upper) and RT-PCR analysis (lower) revealed that increasing expression of RBFOX2 was paralleled by the full-length isoforms of MALT1, CLSTN1, FMNL3, and MYO9B. Exon numbering refers to the following sequences: MALT1 (NM_006785.3), CLSTN1 (NM_001009566), FMNL3 (ENST00000550488.5), MYO9B (NM_001130065). c Transfection with siRNA oligonucleotides efficiently downregulated expression of RBFOX2 mRNA (upper) and protein (medium). Repression of RBFOX2 resulted in an increase of the short isoforms of MALT1, FMNL3 and MYO9B (lower)
See this image and copyright information in PMC

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