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Observational Study
. 2019 Jan;54(1):25-34.
doi: 10.1007/s10840-018-0436-x. Epub 2018 Aug 10.

Utility of acute arrhythmia termination as an ablation endpoint for induced atrial tachyarrhythmia after complete pulmonary vein isolation during catheter ablation for persistent atrial fibrillation

Young Choi  1 , Sung-Hwan Kim  2 , Ju Youn Kim  3 , Yoo Ri Kim  4 , Tae-Seok Kim  5 , Youmi Hwang  6 , Ji-Hoon Kim  6 , Sung-Won Jang  7 , Man Young Lee  8 , Tai-Ho Rho  7 , Yong-Seog Oh  9
Affiliations
Observational Study

Utility of acute arrhythmia termination as an ablation endpoint for induced atrial tachyarrhythmia after complete pulmonary vein isolation during catheter ablation for persistent atrial fibrillation

Young Choi et al. J Interv Card Electrophysiol. 2019 Jan.

Abstract

Purpose: The presence of inducible atrial tachyarrhythmia after pulmonary vein isolation (PVI) during radiofrequency catheter ablation (RFCA) for persistent atrial fibrillation (AF) may indicate the necessity of further substrate modification, but the optimal ablation endpoint is unknown. We sought to assess the impact of procedural termination of inducible atrial tachyarrhythmia after PVI in comparison with continued atrial tachyarrhythmia after PVI.

Methods: Among patients who underwent RFCA for persistent AF, we enrolled 93 patients who were in sinus rhythm after PVI and had inducible atrial tachyarrhythmia and 157 patients with continued atrial tachyarrhythmia after PVI. The impact of acute arrhythmia termination during further substrate modification on recurrence was compared between the two groups.

Results: Acute termination was achieved in 51 (54.8%) patients in the induced arrhythmia group and 61 (38.9%) in the continued arrhythmia group. During a mean 35.8 months, acute termination did not significantly reduce arrhythmia recurrence in the induced arrhythmia group (HR 0.712, 95% CI 0.400-1.266, p = 0.247), while it was associated with improved outcome in the continued arrhythmia group (HR 0.590, 95% CI 0.355-0.979, p = 0.038). Acute termination of either induced atrial tachycardia (AT) or induced AF was not associated with improved procedure outcome. Among the continued arrhythmia group, the benefit of acute termination was statistically significant in AT (HR 0.329, 95% CI 0.108-0.997, p = 0.039), but not in AF (HR 0.704, 95% CI 0.396-1.253, p = 0.233) after PVI.

Conclusions: Acute termination of induced rhythm is not a reliable ablation endpoint during substrate modification in patients with inducible arrhythmia after PVI.

Keywords: Atrial fibrillation; Inducibility; Radiofrequency catheter ablation; Substrate modification.

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References

    1. Circulation. 2000 Nov 21;102(21):2619-28 - PubMed
    1. Circulation. 2004 Jun 22;109(24):3007-13 - PubMed
    1. Circulation. 2004 Nov 2;110(18):2797-801 - PubMed
    1. Eur Heart J. 2006 Nov;27(21):2553-9 - PubMed
    1. J Cardiovasc Electrophysiol. 2009 Apr;20(4):388-94 - PubMed

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