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. 2018 Aug;110(3):387-400.
doi: 10.1016/j.fertnstert.2018.05.009.

The role of immunotherapy in in vitro fertilization: a guideline

Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org  1 ; Practice Committee of the American Society for Reproductive Medicine
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Free article

The role of immunotherapy in in vitro fertilization: a guideline

Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org et al. Fertil Steril. 2018 Aug.
Free article

Abstract

Adjuvant immunotherapy treatments in in vitro fertilization (IVF) aim to improve the outcome of assisted reproductive technology (ART) in both the general ART population as well as subgroups such as patients with recurrent miscarriage or implantation failure. The purpose of this guideline is to evaluate the role of immunomodulating therapy in ART. Unfortunately, many of the evaluated therapies lack robust evidence from well-designed adequately powered randomized controlled trials to support their use. Immunotherapies reviewed in the present document are either not associated with improved live-birth outcome in IVF or have been insufficiently studied to make definitive recommendations.

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