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Review
. 2019 Mar:123:100-109.
doi: 10.1016/j.nbd.2018.08.006. Epub 2018 Aug 9.

Targeting neurodegeneration to prevent post-traumatic epilepsy

Idrish Ali  1 , Juliana C Silva  1 , Shijie Liu  1 , Sandy R Shultz  1 , Patrick Kwan  1 , Nigel C Jones  1 , Terence J O'Brien  2
Affiliations
Review

Targeting neurodegeneration to prevent post-traumatic epilepsy

Idrish Ali et al. Neurobiol Dis. 2019 Mar.

Abstract

In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.

Keywords: Neurodegeneration; Neuroinflammation; Post-traumatic epilepsy; Tauopathies; Traumatic brain injury; β amyloid.

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