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Comparative Study
. 1977 Mar;11(3):402-6.
doi: 10.1128/AAC.11.3.402.

Antibacterial activity of netilmicin, a new aminoglycoside antibiotic, compared with that of gentamicin

I Phillips, A Smith, K Shannon
Comparative Study

Antibacterial activity of netilmicin, a new aminoglycoside antibiotic, compared with that of gentamicin

I Phillips et al. Antimicrob Agents Chemother. 1977 Mar.

Abstract

The antibacterial activity of netilmicin (Sch 20569), a new semisynthetic aminoglycoside, was compared with that of gentamicin against a variety of gram-negative bacteria, staphylococci, and streptococci. Both antibiotics had similar activity against most organisms, but netilmicin had appreciably greater activity against gram-negative organisms that were resistant to gentamicin because these species synthesized aminoglycoside 3-N-acetyltransferase I or aminoglycoside 2''-O-nucleotidyltransferase. Netilmicin was also more active than gentamicin against gentamicin-resistant strains of Staphylococcus aureus that produced two enzymes-aminoglycoside-2''-O-phosphotransferase and aminoglycoside-6'-N-acetyltransferase.

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References

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    1. Antimicrob Agents Chemother. 1976 Jul;10(1):139-45 - PubMed
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