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. 2018 Aug;14(2):170-175.
doi: 10.5152/iao.2018.5109.

The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population

Ning-Chia Chang  1 , Chia-Yen Dai  2 , Wen-Yi Lin  3 , Hua-Ling Yang  4 , Hsun-Mo Wang  5 , Chen-Yu Chien  6 , Meng-Hsuan Hsieh  7 , Kuen-Yao Ho  6
Affiliations

The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population

Ning-Chia Chang et al. J Int Adv Otol. 2018 Aug.

Abstract

Objectives: Age-related hearing impairment (ARHI) is a major disability among the elderly. This study aimed to analyze the association of single nucleotide polymorphisms (SNPs) of metabotropic glutamate receptor 7 (GRM7) gene with ARHI in an elderly population in Taiwan.

Materials and methods: This was a community-based study performed in a metropolitan hospital. Participants ≥65 years of age were recruited. Participants with a pure tone average (PTA) of speech frequencies in the better ear of >35 decibel hearing level (dBHL) were classified into the case group, whereas those with PTA ≤25 dBHL were classified into the control group. The association of SNPs rs11928865, rs1353828, rs9814809, and rs9880404 with ARHI was analyzed.

Results: In 106 cases and 190 controls, alleles of all SNPs were found not to be associated with ARHI. The genotype of rs9880404 was found to be associated with ARHI in a dominant pattern, but the genotypes of rs11928865, rs1353828, and rs9814809 were found not to be associated with ARHI.

Conclusion: GRM7 SNPs are associated with susceptibility to ARHI, but the significance of this finding in a Taiwanese population differed from that observed in European studies. Further studies may help to determine Taiwanese (Asian)-specific SNPs associated with ARHI.

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Conflict of interest statement

Conflict of Interest: The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
The relationships among single nucleotide polymorphisms (SNPs) analyzed in the present study. The numbers in the blocks indicate the r-squared between SNPs. All the LOD scores were >69 (69.39–151.91).
See this image and copyright information in PMC

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