Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions

Giulio Rognini^#^{1

2

3}, Francesco Maria Petrini^#^{1

4}, Stanisa Raspopovic^#⁵, Giacomo Valle^{1

4

6}, Giuseppe Granata⁷, Ivo Strauss^{1

4

6}, Marco Solcà^{1

2}, Javier Bello-Ruiz^{1

2}, Bruno Herbelin^{1

2}, Robin Mange^{1

2}, Edoardo D'Anna^{1

4}, Riccardo Di Iorio⁷, Giovanni Di Pino^{8

9}, David Andreu¹⁰, David Guiraud¹⁰, Thomas Stieglitz¹¹, Paolo Maria Rossini^{7

12}, Andrea Serino^#^{1

2}, Silvestro Micera^#^{13

4

6}, Olaf Blanke^#^{1

2

14}

Affiliations

¹ Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
² Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
³ Laboratory of Robotic Systems, School of Engineering, Ecole Polytechnique Fédérale de Lausanne, Laboratory of Robotic Systems, Switzerland.
⁴ Translational Neural Engineering Laboratory, Institute of Bioengineering, School of Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁵ ETH Zürich, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, TAN E 2, Zürich, Switzerland.
⁶ The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.
⁷ Area of Neurosciences, Policlinic A Gemelli foundation, Catholic University of the Sacred Heart, Rome, Italy.
⁸ Neurophysiology and Neuroengineering of Human-Technology Interaction, Campus Bio-Medico University, Rome, Italy.
⁹ Institute of Neurology, Campus Bio-Medico University, Rome, Italy.
¹⁰ NRIA Camin Team, University of Montpellier - LIRMM 860 Rue Saint Priest, Montpellier, France.
¹¹ Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK, University of Freiburg, Freiburg, Germany.
¹² IRCCS San Raffaele Pisana, Rome, Italy.
¹³ Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland silvestro.micera@epfl.ch.
¹⁴ Department of Neurology, University Hospital of Geneva, Geneva, Switzerland.

^# Contributed equally.

PMID: 30100550
PMCID: PMC6791810
DOI: 10.1136/jnnp-2018-318570

Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions

Giulio Rognini et al. J Neurol Neurosurg Psychiatry. 2019 Jul.

. 2019 Jul;90(7):833-836.

doi: 10.1136/jnnp-2018-318570. Epub 2018 Aug 12.

Authors

Affiliations

¹ Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
² Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
³ Laboratory of Robotic Systems, School of Engineering, Ecole Polytechnique Fédérale de Lausanne, Laboratory of Robotic Systems, Switzerland.
⁴ Translational Neural Engineering Laboratory, Institute of Bioengineering, School of Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁵ ETH Zürich, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, TAN E 2, Zürich, Switzerland.
⁶ The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.
⁷ Area of Neurosciences, Policlinic A Gemelli foundation, Catholic University of the Sacred Heart, Rome, Italy.
⁸ Neurophysiology and Neuroengineering of Human-Technology Interaction, Campus Bio-Medico University, Rome, Italy.
⁹ Institute of Neurology, Campus Bio-Medico University, Rome, Italy.
¹⁰ NRIA Camin Team, University of Montpellier - LIRMM 860 Rue Saint Priest, Montpellier, France.
¹¹ Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK, University of Freiburg, Freiburg, Germany.
¹² IRCCS San Raffaele Pisana, Rome, Italy.
¹³ Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland silvestro.micera@epfl.ch.
¹⁴ Department of Neurology, University Hospital of Geneva, Geneva, Switzerland.

^# Contributed equally.

PMID: 30100550
PMCID: PMC6791810
DOI: 10.1136/jnnp-2018-318570

No abstract available

Keywords: consciousness; electrical stimulation.

PubMed Disclaimer

Conflict of interest statement

Competing interests: SM, SR, FMP hold shares of Sensars Neuroprosthetics, a company working to commercialise novel solutions for transradial amputees.

Figures

**Figure 1**
(A) Prosthesis embodiment. Average ratings of embodiment (Q1–3) and suggestibility items (Q4–5) are shown for all experimental conditions are shown for both patient 1 and patient 2 (see online supplementary material 1). embodiment was highest when VTNS was administered synchronously with illumination of the prosthetic hand (as compared with the asynchronous condition). the synchronous stimulation was characterised by a delay smaller than 10ms between the neurally induced tactile sensation and the visual illumination, whereas in the asynchronous condition the temporal mismatch (1.5–2.5s) between the neural stimulation and the visual illumination was randomly selected on each trial. In patient 1, suggestibility items were always rated 0 (shown as coloured lines). (B) reduction of abnormal phantom limb perceptions (telescoping). to measure the perceived length of the phantom limb, both patients were asked to operate a movable cursor inside a ruler with their right hand. the difference between the perceived position of this phantom finger and elbow was used to estimate the perceived length (in cm) of the phantom limb (average scores are reported). (C) During synchronous VTNS (blue) both perceived the tip of their phantom finger in a more distal position (vs asynchronous condition; p<0.01; red), compatible with an increase in the perceived length of their phantom limb (B; online supplementary video 2). (D) this condition-specific change in telescoping persisted, in both patients, 10min after VTNS had ended. error bars show Se of the mean. *P<0.05; **P<0.01. VTNS, visuo-tactile neural stimulation.

See this image and copyright information in PMC

References

1. Blanke O, Slater M, Serino A. Behavioral, neural, and computational principles of bodily self-consciousness. Neuron. 2015;88:145–66. - PubMed
1. Raspopovic S, Capogrosso M, Petrini FM, et al. Restoring natural sensory feedback in real-time bidirectional hand prostheses. Sci Transl Med. 2014;6:ra219. - PubMed
1. Ehrsson HH, Rosén B, Stockselius A, et al. Upper limb amputees can be induced to experience a rubber hand as their own. Brain. 2008;131(Pt 12):3443–52. - PMC - PubMed
1. Schiefer M, Tan D, Sidek SM, et al. Sensory feedback by peripheral nerve stimulation improves task performance in individuals with upper limb loss using a myoelectric prosthesis. J Neural Eng. 2016;13 016001. - PMC - PubMed
1. Marasco PD, Kim K, Colgate JE, et al. Robotic touch shifts perception of embodiment to a prosthesis in targeted reinnervation amputees. Brain. 2011;134(Pt 3):747–58. - PMC - PubMed

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Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions

Affiliations

Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions

Authors

Affiliations

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical