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Randomized Controlled Trial
. 2019 Feb;74(2):206-207.
doi: 10.1136/thoraxjnl-2018-211931. Epub 2018 Aug 12.

CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema

Karin J C Sanders  1 , Karin Klooster  2 , Lowie E G W Vanfleteren  3 , Dirk-Jan Slebos  2 , Annemie M W J Schols  1
Affiliations
Randomized Controlled Trial

CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema

Karin J C Sanders et al. Thorax. 2019 Feb.

Abstract

Muscle wasting frequently occurs in severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction using endobronchial valves (EBV) might prevent further loss or even increase in muscle mass. CT-derived skeletal muscle mass gain was observed in 39/49 patients 6 months after EBV. Multiple linear regression showed that gain in muscle (β=2.4; 95% CI 0.2 to 4.6; p=0.036) and intramuscular fat (β=3.1; 95% CI 0.2 to 5.9; p=0.035) is associated with improved 6 min walk distance independent of the change in residual volume. Skeletal muscle remodelling associates with improved exercise capacity after EBV, independent of hyperinflation reduction. TRIAL REGISTRATION NUMBER: Clinical trial registered with the Dutch trial register www.trialregister.nl (NTR2876), Results.

Keywords: emphysema; imaging/ct mri etc; lung volume reduction surgery; systemic disease and lungs.

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Conflict of interest statement

Competing interests: KJCS has nothing to disclose. KK reports non-financial support from ZonMW, The Hague, NL (government granting agency), during the conduct of the study; grants, personal fees, non-financial support and other from PneumRx/BTG, CA, USA, grants, personal fees, non-financial support and other from PulmonX, CA, USA, outside the submitted work. LEGWV has nothing to disclose. D-JS reports grants, personal fees, non-financial support and other from PulmonX Inc., CA, USA, outside the submitted work. AMWJS has nothing to disclose.

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