Power, Ethics and Obligation

Affiliations

¹ UT Health Science Center San Antonio, Department of Epidemiology and Biostatistics, Mail Code 7933, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, U.S.A.
² Vanderbilt University Medical Center, Center for Biomedical Ethics and Society, 2525 West End Avenue, Suite 400, Nashville, Tennessee 37203, U.S.A.
³ UT Health Science Center San Antonio, Department of Epidemiology and Biostatistics, San Antonio, Texas 78229-3900, U.S.A.
⁴ UT Health Science Center San Antonio, Department of Medicine, San Antonio, Texas 78229, U.S.A.

Comment

Jonathan Adam Gelfond et al. Stat Med. 2012.

. 2012 Dec 20;31(29):4140-4141.

doi: 10.1002/sim.5578. Epub 2012 Nov 23.

¹ UT Health Science Center San Antonio, Department of Epidemiology and Biostatistics, Mail Code 7933, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, U.S.A.
² Vanderbilt University Medical Center, Center for Biomedical Ethics and Society, 2525 West End Avenue, Suite 400, Nashville, Tennessee 37203, U.S.A.
³ UT Health Science Center San Antonio, Department of Epidemiology and Biostatistics, San Antonio, Texas 78229-3900, U.S.A.
⁴ UT Health Science Center San Antonio, Department of Medicine, San Antonio, Texas 78229, U.S.A.

No abstract available

Comment on

Ethics and sample size.
Bacchetti P, Wolf LE, Segal MR, McCulloch CE. Bacchetti P, et al. Am J Epidemiol. 2005 Jan 15;161(2):105-10. doi: 10.1093/aje/kwi014. Am J Epidemiol. 2005. PMID: 15632258
Simple, defensible sample sizes based on cost efficiency.
Bacchetti P, McCulloch CE, Segal MR. Bacchetti P, et al. Biometrics. 2008 Jun;64(2):577-85; discussion 586-94. doi: 10.1111/j.1541-0420.2008.01004_1.x. Biometrics. 2008. PMID: 18482055 Free PMC article.

1. Shuster E. The Nuremberg Code: Hippocratic ethics and human rights. Lancet. 1998;351(9107):974–977. - PubMed
1. Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med. 2006;355(10):1018–1028. - PubMed
1. Bacchetti P, McCulloch CE, Segal MR. Simple, defensible sample sizes based on cost efficiency. Biometrics. 2008;64(2):577–585. - PMC - PubMed
1. Bacchetti P, Wolf LE, Segal MR, McCulloch CE. Ethics and sample size. Am J Epidemiol. 2005;161(2):105–110. - PubMed
1. Halpern SD, Karlawish JHT, Berlin JA. The continuing unethical conduct of underpowered clinical trials. Jama-Journal of the American Medical Association. 2002;288(3):358–362. - PubMed