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Review
. 1986 Apr;320(6063):584-8.
doi: 10.1038/320584a0.

Cachectin and tumour necrosis factor as two sides of the same biological coin

B Beutler, A Cerami
Review

Cachectin and tumour necrosis factor as two sides of the same biological coin

B Beutler et al. Nature. 1986 Apr.

Abstract

In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

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