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. 2019 Feb 15;35(4):685-687.
doi: 10.1093/bioinformatics/bty679.

LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics

Eoin Fahy  1 , Jorge Alvarez-Jarreta  2 , Christopher J Brasher  2 , An Nguyen  3 , Jade I Hawksworth  2 , Patricia Rodrigues  2 , Sven Meckelmann  2 , Stuart M Allen  4 , Valerie B O'Donnell  2
Affiliations

LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics

Eoin Fahy et al. Bioinformatics. .

Abstract

Summary: We present LipidFinder online, hosted on the LIPID MAPS website, as a liquid chromatography/mass spectrometry (LC/MS) workflow comprising peak filtering, MS searching and statistical analysis components, highly customized for interrogating lipidomic data. The online interface of LipidFinder includes several innovations such as comprehensive parameter tuning, a MS search engine employing in-house customized, curated and computationally generated databases and multiple reporting/display options. A set of integrated statistical analysis tools which enable users to identify those features which are significantly-altered under the selected experimental conditions, thereby greatly reducing the complexity of the peaklist prior to MS searching is included. LipidFinder is presented as a highly flexible, extensible user-friendly online workflow which leverages the lipidomics knowledge base and resources of the LIPID MAPS website, long recognized as a leading global lipidomics portal.

Availability and implementation: LipidFinder on LIPID MAPS is available at: http://www.lipidmaps.org/data/LF.

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Figures

Fig. 1.
Fig. 1.
LipidFinder online workflow. Once the file is processed by LipidFinder’s PeakFilter module, users have the option of running a set of statistical analyses to refine the peaklist prior to MS searching. Move this so just under the figure
See this image and copyright information in PMC

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