Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1986 Feb;11(2):173-83.
doi: 10.1007/BF00967966.

Proteolysis in quaking mouse brain and spinal cord

W W McAlhaney, N L Banik, S Greenfield, E L Hogan
Comparative Study

Proteolysis in quaking mouse brain and spinal cord

W W McAlhaney et al. Neurochem Res. 1986 Feb.

Abstract

Six proteolytic enzymes were assayed for activity in quaking CNS in examining the hypothesis that increased proteolytic activity contributes to the hypomyelination characteristics of this mutant. Cathepsin B-like enzyme, cathepsin D, neutral proteinase, calcium-activated neutral proteinase, prolyl endopeptidase, and diaminopeptidase II were assayed in whole homogenate of brain or spinal cord and each was found to have activity similar to that in normal mice. These results do not support a relationship between proteolysis and the genetic defect and suggest that other factors should be investigated to delineate the pathogenesis of this mutant.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. J Neurol Sci. 1982 Nov;56(2-3):141-5 - PubMed
    1. Histochem J. 1969 Nov;1(6):559-78 - PubMed
    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Ann Neurol. 1978 Oct;4(4):337-44 - PubMed
    1. J Neurochem. 1974 Nov;23(5):935-41 - PubMed

Publication types