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. 2018 Nov 5;218(12):2016-2019.
doi: 10.1093/infdis/jiy492.

A Single-Nucleotide Polymorphism Upstream of the HLA-C Locus Is Associated With an Anti-Hepatitis C Virus-Seronegative State in a High-Risk Exposed Cohort

Christine Thoens  1 , Andreas Heinold  2 , Monika Lindemann  2 , Peter A Horn  2 , Dae-In Chang  3 , Norbert Scherbaum  3 , Joerg Timm  1 , Falko M Heinemann  2
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A Single-Nucleotide Polymorphism Upstream of the HLA-C Locus Is Associated With an Anti-Hepatitis C Virus-Seronegative State in a High-Risk Exposed Cohort

Christine Thoens et al. J Infect Dis. .

Abstract

In this study, we examined the impact of the rs9264942 single-nucleotide polymorphism, previously shown to be associated with human immunodeficiency virus infection status and HLA-C expression, on the hepatitis C virus status in 359 people who inject drugs (PWID). The linkage of rs9264942 alleles to HLA-C antigens assigned to different expression levels was confirmed. Multivariate analysis revealed the age (P = .003) and the rs9264942 genotype (P = .006) to be independent factors for the classification to the PWID groups. Our study showed that the presence of the rs9264942 C/C genotype was associated with persistent seronegativity.

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