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. 2018 Nov;35(11):1073-1080.
doi: 10.1002/da.22807. Epub 2018 Aug 13.

Predeployment predictors of psychiatric disorder-symptoms and interpersonal violence during combat deployment

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Predeployment predictors of psychiatric disorder-symptoms and interpersonal violence during combat deployment

Anthony J Rosellini et al. Depress Anxiety. 2018 Nov.

Abstract

Background: Preventing suicides, mental disorders, and noncombat-related interpersonal violence during deployment are priorities of the US Army. We used predeployment survey and administrative data to develop actuarial models to identify soldiers at high risk of these outcomes during combat deployment.

Methods: The models were developed in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) Pre-Post Deployment Study, a panel study of soldiers deployed to Afghanistan in 2012-2013. Soldiers completed self-administered questionnaires before deployment and one (T1), three (T2), and nine months (T3) after deployment, and consented to administrative data linkage. Seven during-deployment outcomes were operationalized using the postdeployment surveys. Two overlapping samples were used because some outcomes were assessed at T1 (n = 7,048) and others at T2-T3 (n = 7,081). Ensemble machine learning was used to develop a model for each outcome from 273 predeployment predictors, which were compared to simple logistic regression models.

Results: The relative improvement in area under the receiver operating characteristic curve (AUC) obtained by machine learning compared to the logistic models ranged from 1.11 (major depression) to 1.83 (suicidality).The best-performing machine learning models were for major depression (AUC = 0.88), suicidality (0.86), and generalized anxiety disorder (0.85). Roughly 40% of these outcomes occurred among the 5% of soldiers with highest predicted risk.

Conclusions: Actuarial models could be used to identify high risk soldiers either for exclusion from deployment or preventive interventions. However, the ultimate value of this approach depends on the associated costs, competing risks (e.g. stigma), and the effectiveness to-be-determined interventions.

Keywords: army; deployment; mental disorder; military; predictive modeling; risk assessment; violence.

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Conflict of interest statement

Conflict of interest disclosures: Dr. Stein has been a consultant for Care Management Technologies, received payment for his editorial work from UpToDate and Depression and Anxiety, and had research support for pharmacological imaging studies from Janssen. Dr. Monahan is a co-owner of the Classification of Violence Risk (COVR), Inc. In the past 3 years, Dr. Kessler received support for his epidemiological studies from Sanofi Aventis; was a consultant for Johnson & Johnson Wellness and Prevention, Shire, Takeda; and served on an advisory board for the Johnson & Johnson Services Inc. Lake Nona Life Project. Kessler is a co-owner of DataStat, Inc., a market research firm that carries out healthcare research. The remaining authors report nothing to disclose.

Figures

Figure 1
Figure 1. Proportion of outcomes (observed) within each ventile of predicted risk derived from the final super learner modelsa
aVentiles are 20 groups created by dividing the sample into 20 equally sized groups defined by rank order of predicted risk from the final penalized models.

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