Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Dec;40(12):2714-2723.
doi: 10.1002/hed.25366. Epub 2018 Aug 13.

Platelet count and platelet-lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta-analysis

Yukinori Takenaka  1 , Ryohei Oya  1 , Takahiro Kitamiura  1 , Naoki Ashida  1 , Kotaro Shimizu  1 , Kazuya Takemura  1 , Yoshifumi Yamamoto  1 , Atsuhiko Uno  1
Affiliations
Meta-Analysis

Platelet count and platelet-lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta-analysis

Yukinori Takenaka et al. Head Neck. 2018 Dec.

Abstract

Background: Thrombocytosis is associated with the prognosis of various types of cancer. The purpose of this study was to quantify the prognostic impact of platelet count and platelet-lymphocyte ratio (PLR) in head and neck squamous cell carcinoma (HNSCC).

Methods: We systematically searched electronic databases and identified articles reporting an association between platelet count or PLR and HNSCC prognosis. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS) were extracted, and the pooled HRs were estimated using random effect models.

Results: Eight studies that enrolled 4096 patients and 9 studies that enrolled 2327 patients were included in the platelet count and PLR analyses, respectively. A platelet count greater than the cutoff value was associated with poor OS (HR 1.81; 95% CI 1.16-2.82) and any PLR greater than the cutoff value was associated with poor OS (HR 1.64; 95% CI 1.13-2.37).

Conclusion: Elevated platelet count and PLR are associated with poor prognosis in patients with HNSCC.

Keywords: head and neck cancer; inflammation; lymphocyte; platelet; thrombocytosis.

PubMed Disclaimer

LinkOut - more resources