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Review
. 2018 Oct;17(10):990-1001.
doi: 10.1016/j.autrev.2018.04.006. Epub 2018 Aug 11.

Recommendations and barriers to vaccination in systemic lupus erythematosus

Megha Garg  1 , Naaima Mufti  2 , Tara N Palmore  3 , Sarfaraz A Hasni  4
Affiliations
Review

Recommendations and barriers to vaccination in systemic lupus erythematosus

Megha Garg et al. Autoimmun Rev. 2018 Oct.

Abstract

Patients with Systemic Lupus Erythematosus (SLE) pose a unique dilemma pertaining to immunization against common pathogens. SLE patients are usually not immunized with vaccines based on the fear of either precipitating infection in this immunosuppressed patient population (with live vaccines) or aggravating autoimmunity and hence lupus flares (with any vaccines). However, elevated vulnerability to infection makes patients with SLE precisely the population that needs protection from vaccine-preventable diseases. A summary of guidelines from the Centers for Disease Control and Prevention, professional societies, review articles and expert opinions regarding use of individual vaccines applicable to adults with SLE is presented in this review.

Keywords: Lupus; Vaccination.

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Conflict of interest statement

Conflict of interest: None

References

    1. Millet A, Decaux O, Perlat A, Grosbois B and Jego P, Systemic lupus erythematosus and vaccination, Eur J Intern Med 20 (2009) 236–41. - PubMed
    1. Piliero P and Furie R, Functional asplenia in systemic lupus erythematosus, Semin Arthritis Rheum 20 (1990) 185–9. - PubMed
    1. Sullivan KE, Wooten C, Goldman D and Petri M, Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus, Arthritis Rheum 39 (1996) 2046–51. - PubMed
    1. Garred P, Madsen HO, Halberg P, Petersen J, Kronborg G, Svejgaard A, Andersen V and Jacobsen S, Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus, Arthritis Rheum 42 (1999) 2145–52. - PubMed
    1. Bartholomew WR and Shanahan TC, Complement components and receptors: deficiencies and disease associations, Immunol Ser 52 (1990) 33–51. - PubMed

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