Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Oct;17(10):990-1001.
doi: 10.1016/j.autrev.2018.04.006. Epub 2018 Aug 11.

Recommendations and barriers to vaccination in systemic lupus erythematosus

Megha Garg  1 , Naaima Mufti  2 , Tara N Palmore  3 , Sarfaraz A Hasni  4
Affiliations
Review

Recommendations and barriers to vaccination in systemic lupus erythematosus

Megha Garg et al. Autoimmun Rev. 2018 Oct.

Abstract

Patients with Systemic Lupus Erythematosus (SLE) pose a unique dilemma pertaining to immunization against common pathogens. SLE patients are usually not immunized with vaccines based on the fear of either precipitating infection in this immunosuppressed patient population (with live vaccines) or aggravating autoimmunity and hence lupus flares (with any vaccines). However, elevated vulnerability to infection makes patients with SLE precisely the population that needs protection from vaccine-preventable diseases. A summary of guidelines from the Centers for Disease Control and Prevention, professional societies, review articles and expert opinions regarding use of individual vaccines applicable to adults with SLE is presented in this review.

Keywords: Lupus; Vaccination.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None

Similar articles

  • [Prevention of infections in adults and adolescents with systemic lupus erythematosus: Guidelines for the clinical practice based on the literature and expert opinion].
    Mathian A, Arnaud L, Adoue D, Agard C, Bader-Meunier B, Baudouin V, Belizna C, Bonnotte B, Boumedine F, Chaib A, Chauchard M, Chiche L, Daugas E, Ghali A, Gobert P, Gondran G, Guettrot-Imbert G, Hachulla E, Hamidou M, Haroche J, Hervier B, Hummel A, Jourde-Chiche N, Korganow AS, Kwon T, Le Guern V, Le Quellec A, Limal N, Magy-Bertrand N, Marianetti-Guingel P, Martin T, Martin Silva N, Meyer O, Miyara M, Morell-Dubois S, Ninet J, Pennaforte JL, Polomat K, Pourrat J, Queyrel V, Raymond I, Remy P, Sacre K, Sibilia J, Viallard JF, Viau Brabant A, Hanslik T, Amoura Z; le groupe France lupus érythémateux systémique réseau (FLEUR) et les centres de référence et de compétence des lupus et syndromes des antiphospholipides. Mathian A, et al. Rev Med Interne. 2016 May;37(5):307-20. doi: 10.1016/j.revmed.2016.01.005. Epub 2016 Feb 16. Rev Med Interne. 2016. PMID: 26899776 French.
  • Herpes zoster vaccination in systemic lupus erythematosus: the current status.
    Mok CC. Mok CC. Hum Vaccin Immunother. 2019;15(1):45-48. doi: 10.1080/21645515.2018.1514228. Epub 2018 Sep 5. Hum Vaccin Immunother. 2019. PMID: 30130445 Free PMC article.
  • Vaccination in SLE patients.
    Htut E, Hall F. Htut E, et al. Lupus. 2018 Oct;27(1_suppl):36-39. doi: 10.1177/0961203318801697. Lupus. 2018. PMID: 30452324 No abstract available.
  • Immunisation of the immunocompromised child.
    Pinto MV, Bihari S, Snape MD. Pinto MV, et al. J Infect. 2016 Jul 5;72 Suppl:S13-22. doi: 10.1016/j.jinf.2016.04.017. Epub 2016 May 24. J Infect. 2016. PMID: 27233121 Review.
  • Systemic lupus erythematosus and vaccination.
    Millet A, Decaux O, Perlat A, Grosbois B, Jego P. Millet A, et al. Eur J Intern Med. 2009 May;20(3):236-41. doi: 10.1016/j.ejim.2008.07.017. Epub 2008 Aug 29. Eur J Intern Med. 2009. PMID: 19393490 Review.
See all similar articles

Cited by

See all "Cited by" articles

References

    1. Millet A, Decaux O, Perlat A, Grosbois B and Jego P, Systemic lupus erythematosus and vaccination, Eur J Intern Med 20 (2009) 236–41. - PubMed
    1. Piliero P and Furie R, Functional asplenia in systemic lupus erythematosus, Semin Arthritis Rheum 20 (1990) 185–9. - PubMed
    1. Sullivan KE, Wooten C, Goldman D and Petri M, Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus, Arthritis Rheum 39 (1996) 2046–51. - PubMed
    1. Garred P, Madsen HO, Halberg P, Petersen J, Kronborg G, Svejgaard A, Andersen V and Jacobsen S, Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus, Arthritis Rheum 42 (1999) 2145–52. - PubMed
    1. Bartholomew WR and Shanahan TC, Complement components and receptors: deficiencies and disease associations, Immunol Ser 52 (1990) 33–51. - PubMed

MeSH terms