doi: 10.1073/pnas.83.9.2802.
Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive enhancer system
- PMID: 3010318
- PMCID: PMC323394
- DOI: 10.1073/pnas.83.9.2802
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Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive enhancer system
Proc Natl Acad Sci U S A.
1986 May.
Abstract
We analyzed the function and sequence of a dioxin-responsive genomic element flanking the 5' end of the cytochrome P1-450 gene in high-activity variant mouse hepatoma cells. The element can regulate the mouse mammary tumor virus promoter. The element retains responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) when the distance, the 5' or 3' position, and/or the 5' or 3' orientation with respect to the promoter are varied. The function of the element requires TCDD-receptor complexes. The element remains responsive to TCDD when transfected into cells from either a heterologous mouse tissue or a heterologous species (human). The DNA element and TCDD receptors together constitute a dioxin-responsive enhancer system.
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