Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Aug 10;5(3):87.
doi: 10.3390/medicines5030087.

Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer

Yasuyoshi Miyata  1 , Tomohiro Matsuo  2 , Kyohei Araki  3 , Yuichiro Nakamura  4 , Yuji Sagara  5 , Kojiro Ohba  6 , Hideki Sakai  7
Affiliations
Review

Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer

Yasuyoshi Miyata et al. Medicines (Basel). .

Abstract

Green tea and green tea polyphenols (GTPs) are reported to inhibit carcinogenesis and malignant behavior in several diseases. Various in vivo and in vitro studies have shown that GTPs suppress the incidence and development of bladder cancer. However, at present, opinions concerning the anticancer effects and preventive role of green tea are conflicting. In addition, the detailed molecular mechanisms underlying the anticancer effects of green tea in bladder cancer remain unclear, as these effects are regulated by several cancer-related factors. A detailed understanding of the pathological roles and regulatory mechanisms at the molecular level is necessary for advancing treatment strategies based on green tea consumption for patients with bladder cancer. In this review, we discuss the anticancer effects of GTPs on the basis of data presented in in vitro studies in bladder cancer cell lines and in vivo studies using animal models, as well as new treatment strategies for patients with bladder cancer, based on green tea consumption. Finally, on the basis of the accumulated data and the main findings, we discuss the potential usefulness of green tea as an antibladder cancer agent and the future direction of green tea-based treatment strategies for these patients.

Keywords: animal model; bladder cancer; epidemiology; green tea; treatment.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cooper R., Morré D.J., Morré D.M. Medicinal benefits of green tea: Part I. Review of noncancer health benefits. J. Altern. Complement. Med. 2005;11:521–528. doi: 10.1089/acm.2005.11.521. - DOI - PubMed
    1. Bedrood Z., Rameshrad M., Hosseinzadeh H. Toxicological effects of Camellia sinensis (green tea): A review. Phytother. Res. 2018;32:1163–1180. doi: 10.1002/ptr.6063. - DOI - PubMed
    1. Surh Y.J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer. 2003;3:768–780. doi: 10.1038/nrc1189. - DOI - PubMed
    1. Yang C.S., Wang X., Lu G., Picinich S.C. Cancer prevention by tea: Animal studies, molecular mechanisms and human relevance. Nat. Rev. Cancer. 2009;9:429–439. doi: 10.1038/nrc2641. - DOI - PMC - PubMed
    1. Bag A., Bag N. Tea polyphenols and prevention of epigenetic aberrations in cancer. J. Nat. Sci. Biol. Med. 2018;9:2–5. doi: 10.4103/jnsbm.JNSBM_46_17. - DOI - PMC - PubMed

LinkOut - more resources