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. 2018 Aug 11;23(8):2008.
doi: 10.3390/molecules23082008.

A New Method for Recognizing Cytokines Based on Feature Combination and a Support Vector Machine Classifier

Zhe Yang  1 , Juan Wang  2 , Zhida Zheng  3 , Xin Bai  4
Affiliations

A New Method for Recognizing Cytokines Based on Feature Combination and a Support Vector Machine Classifier

Zhe Yang et al. Molecules. .

Abstract

Research on cytokine recognition is of great significance in the medical field due to the fact cytokines benefit the diagnosis and treatment of diseases, but the current methods for cytokine recognition have many shortcomings, such as low sensitivity and low F-score. Therefore, this paper proposes a new method on the basis of feature combination. The features are extracted from compositions of amino acids, physicochemical properties, secondary structures, and evolutionary information. The classifier used in this paper is SVM. Experiments show that our method is better than other methods in terms of accuracy, sensitivity, specificity, F-score and Matthew's correlation coefficient.

Keywords: PSSM; PseAAC; SVM; cytokines; feature combination.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison between our method and the 473+SVM.
Figure 2
Figure 2
Comparison between our method and the MRDR+LIBD3C.
Figure 3
Figure 3
Comparison between our method and the PCA+BP-NN.
Figure 4
Figure 4
Overview of feature extraction.
See this image and copyright information in PMC

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References

    1. Sutovsky J., Kocmalova M., Benco M., Kazimierova I., Pappova L., Frano A., Sutovska M. The role of cytokines in degenerative spine disorders. Eur. Pharm. J. 2017;64:26–29. doi: 10.1515/afpuc-2017-0007. - DOI
    1. Vandergeeten C., Fromentin R., Chomont N. The role of cytokines in the establishment, persistence and eradication of the hiv reservoir. Cytokine Growth Factor Rev. 2012;23:143–149. doi: 10.1016/j.cytogfr.2012.05.001. - DOI - PMC - PubMed
    1. Si M., Jiao X., Li Y., Chen H., He P., Jiang F. The role of cytokines and chemokines in the microenvironment of the blood–brain barrier in leukemia central nervous system metastasis. Cancer Manag. Res. 2018;10:305–313. doi: 10.2147/CMAR.S152419. - DOI - PMC - PubMed
    1. Musolino C., Allegra A., Innao V., Allegra A.G., Pioggia G., Gangemi S. Inflammatory and anti-inflammatory equilibrium, proliferative and antiproliferative balance: The role of cytokines in multiple myeloma. Mediat. Inflamm. 2017;2017:1852517. doi: 10.1155/2017/1852517. - DOI - PMC - PubMed
    1. Champsi J.H., Bermudez L.E., Young L.S. The role of cytokines in mycobacterial infection. Biotherapy. 1994;7:187–193. doi: 10.1007/BF01878485. - DOI - PubMed

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