Using Anesthesia to Reveal the Elements of Consciousness
- PMID: 30104140
- PMCID: PMC6979465
- DOI: 10.1016/j.tics.2018.07.016
Using Anesthesia to Reveal the Elements of Consciousness
Abstract
General anesthesia provides an invaluable experimental tool to probe the essential neural circuits that underlie consciousness. A new study reports that cholinergic stimulation of the prefrontal cortex restores wake-like behaviors in anesthetized rodents, suggesting that cholinergic inputs to the prefrontal cortex play a fundamental role in modulating consciousness.
Keywords: acetylcholine; norepinephrine; prefrontal cortex; sevoflurane.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Comment on
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Differential Role of Prefrontal and Parietal Cortices in Controlling Level of Consciousness.Curr Biol. 2018 Jul 9;28(13):2145-2152.e5. doi: 10.1016/j.cub.2018.05.025. Epub 2018 Jun 21. Curr Biol. 2018. PMID: 29937348 Free PMC article.
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