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Case Reports
. 2018 Aug 13;190(32):E961.
doi: 10.1503/cmaj.180231.

Reversible cerebellar neurotoxicity induced by metronidazole

Ariel Lefkowitz  1 , Steven Shadowitz  2
Affiliations
Case Reports

Reversible cerebellar neurotoxicity induced by metronidazole

Ariel Lefkowitz et al. CMAJ. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1:
Figure 1:
A) Magnetic resonance image (axial view) of the brain in a 59-year-old man with cerebellar neurotoxicity induced by metronidazole, showing fluid-attenuated inversion recovery (FLAIR) signal changes in the dentate nuclei bilaterally( arrows). FLAIR signal hyperintensity is also seen in the inferior aspect of the cerebellar peduncles bilaterally, which is an artifact. Diffusion restriction was seen in the dentate nuclei on the dedicated diffusion weighted imaging sequence (not shown). B) Axial section of the brain of the same patient four weeks after he stopped taking metronidazole, showing resolution of the abnormalities in the dentate nuclei.
See this image and copyright information in PMC

References

    1. Bond KM, Brinjikji W, Eckel LJ, et al. Dentate update: imaging features of entities that affect the dentate nucleus. AJNR Am J Neuroradiol 2017;38:1467–74. - PMC - PubMed
    1. Woodruff BK, Wijdicks EF, Marshall WF, et al. Reversible metronidazole-induced lesions of the cerebellar dentate nuclei. N Engl J Med 2002;346:68–9. - PubMed
    1. Sarna JR, Furtado S, Brownell AK. Neurologic complications of metronidazole. Can J Neurol Sci 2013;40:768–76. - PubMed
    1. Heaney CJ, Campeau NG, Lindell EP, et al. MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity. AJNR Am J Neuroradiol 2003;24:1615–7. - PMC - PubMed

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