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. 2018 Aug 13;23(8):2013.
doi: 10.3390/molecules23082013.

Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations

Ricardo A Murcia  1 , Sandra M Leal  2   3 , Martha V Roa  4   5 , Edgar Nagles  6 , Alvaro Muñoz-Castro  7 , John J Hurtado  8
Affiliations

Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations

Ricardo A Murcia et al. Molecules. .

Abstract

In this work, six complexes (2⁻7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3⁻7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL-1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.

Keywords: antibacterial activity; antifungal activity; cobalt(II) and chromium(III) complexes; triazole ligands.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Synthesis of the ligand (1).
Figure 1
Figure 1
Possible structures of the complexes under study.
Figure 2
Figure 2
Atom numbering for signal assignment for 1,2,4-triazole.
Figure 3
Figure 3
Optimized geometries for complexes 2–7.
Figure 4
Figure 4
Molecular electrostatic potential maps of the studied complexes denoting their permanent dipole moments in Debye (D). Blue regions indicate charge depletion, and red regions indicate charge accumulation.
Figure 5
Figure 5
Atom numbering for signal assignment of the NMR for 1.
See this image and copyright information in PMC

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