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. 1977 Jul;37(7 Pt 1):2030-5.

Marker properties of tumor and lymphoid cell lines derived from a patient with squamous cell carcinoma

R T Morgan, L A Quinn, L K Woods, G E Moore
  • PMID: 301054

Marker properties of tumor and lymphoid cell lines derived from a patient with squamous cell carcinoma

R T Morgan et al. Cancer Res. 1977 Jul.

Abstract

A squamous cell carcinoma tumor cell line, COLO 227, derived from a metastatic tumor in a Caucasian male, produces both parathyroid hormone and carcinoembryonic antigen. A chromosome mode of 106 predominated and the X and Y chromosomes were retained. Seven marker chromosomes were identified. Cytogenetic analysis revealed an isochromosome 8 marker similar to a HeLa cell line marker and an isochromosome 17 marker described in other cancers. An autochthonous lymphoid cell line, COLO 219, was established and characterized. COLO 219 is a normal lymphoid cell line with B-cell characteristics. This autochthonous system of both cultured tumor cells and cultured lymphocytes is of use in immunological studies.

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