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. 2018 Nov 1;22(4):375-380.
doi: 10.5935/1518-0557.20180050.

Genetic counseling prior to Assisted Reproductive Technology procedures in the era of cytogenomics

Roberto Coco  1
Affiliations

Genetic counseling prior to Assisted Reproductive Technology procedures in the era of cytogenomics

Roberto Coco. JBRA Assist Reprod. .

Abstract

The possibility of sequencing hundreds of genes simultaneously and performing molecular karyotyping thanks to the introduction of novel genetic tools has expanded the use of preconception screening for blastocyst recessive mutations and aneuploidies before embryo transfer, with the ultimate purpose of increasing the proportion of normal healthy newborns. Since medically-assisted reproduction procedures are increasingly required to be eugenic, and the aforementioned genetic tests cover only half of the potential genetic diseases occurring at birth, it seems reasonable to incorporate genetic counseling in the practice of assisted reproduction to avoid prosecution for malpractice.

Keywords: NGS; PGT-A; PGT-M; assisted reproductive technologies; genetic counseling; genetic testing.

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References

    1. ACOG - American College of Obstetricians and Gynecologists Committee on Genetics. Committee opinion No 691: Carrier screening for genetic conditions. Obstet Gynecol. 2017;129:e41-e55. - PubMed
    1. Chandley AC. Chromosomes. In: Hargreave TB, editor. Male Infertility. Berlin: Springer-Verlag; 1983. pp. 144–159.
    1. Davies MJ, Moore VM, Willson KJ, Van Essen P, Priest K, Scott H, Haan EA, Chan A. Reproductive technologies and the risk of birth defects. N Engl J Med. 2012;366:1803–1813. doi: 10.1056/NEJMoa1008095. - DOI - PubMed
    1. Ericson A, Källén B. Congenital malformations in infants born after IVF: a population-based study. Hum Reprod. 2001;16:504–509. doi: 10.1093/humrep/16.3.504. - DOI - PubMed
    1. Farhangniya M, Dortaj Rabori E, Mozafari Kermani R, Haghdoost AA, Bahrampour A, Bagheri P, A L Lancaster P, Ashrafi M, Vosough Taqi Dizaj A, Gourabi H, Shahzadeh Fazeli A. Comparison of Congenital Abnormalities of Infants Conceived by Assisted Reproductive Techniques versus Infants with Natural Conception in Tehran. Int J Fertil Steril. 2013;7:217–224. - PMC - PubMed