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. 2018 Aug 13;34(2):179-180.
doi: 10.1016/j.ccell.2018.07.011.

Tandem Duplications May Supply the Missing Genetic Alterations in Many Triple-Negative Breast and Gynecological Cancers

Manisha Rao  1 , Scott Powers  2
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Tandem Duplications May Supply the Missing Genetic Alterations in Many Triple-Negative Breast and Gynecological Cancers

Manisha Rao et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Menghi et al. show that tandem duplications (TDs) are a common genetic feature of gynecological and triple-negative breast cancers. They also provide evidence that these TDs generate genetic alterations driving these cancers, which, if substantiated, will fundamentally change our understanding of their oncogenesis.

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