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. 1977 Mar;27(3):507-11.

T lymphocytes and the transfer of immunity to Trypanosoma musculi in mice

P Pouliot, P Viens, G A Targett

T lymphocytes and the transfer of immunity to Trypanosoma musculi in mice

P Pouliot et al. Clin Exp Immunol. 1977 Mar.

Abstract

Trypanosoma musculi produces a resolving infection in mice and the immune response is thymus dependent. Spleen cells from immune and from uninfected mice were transferred to T cell-deprived mice and restored their ability to control the infection, the immune cells being effective most rapidly. Treatment of the cells in vitro with anti-theta serum did not impair their ability to restore immunocompetence and it is proposed that, though T-cell dependent, the immune response is effected by theta- cells.

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