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Comment
. 2018 Sep 3;217(9):2983-2985.
doi: 10.1083/jcb.201807105. Epub 2018 Aug 14.

Natural killers shed attachments to kill again

James H Felce  1 , Michael L Dustin  2
Affiliations
Comment

Natural killers shed attachments to kill again

James H Felce et al. J Cell Biol. .

Abstract

Natural killer cells target antibody-bound cells following engagement of the Fc receptor CD16. Srpan et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201712085) reveal that activation-induced shedding of CD16 leads to more motile behavior, allowing more targets to be engaged and killed in a given time.

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Figures

Figure 1.
Figure 1.
NK cell killing can be achieved through stable or mobile contacts. (A) Synapses are symmetrical, stable structures formed between NK cells and target cells, whereas kinapses are polarized, motile interactions. (B) Persistent interaction of NK-bound CD16 with target-bound antibody promotes a synaptic structure. (C) Conversely, activation-induced shedding of CD16 allows NK cells to adopt more kinaptic structures, shortening contacts with individual cells while promoting durable contact with a continuous target tissue and increasing the overall rate of killing. It is not clear whether kinapses form on first engagement of CD16 or emerge from synapses formed with originally encountered cells.
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