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Comparative Study
. 1986 Apr;29(4):660-2.
doi: 10.1128/AAC.29.4.660.

Comparison of the in vitro and in vivo activity of the bis-triazole derivative UK 49,858 with that of amphotericin B against Histoplasma capsulatum

G S Kobayashi, S Travis, G Medoff
Comparative Study

Comparison of the in vitro and in vivo activity of the bis-triazole derivative UK 49,858 with that of amphotericin B against Histoplasma capsulatum

G S Kobayashi et al. Antimicrob Agents Chemother. 1986 Apr.

Abstract

The antifungal activity of UK 49,858, a difluorophenyl bis-triazole derivative, was evaluated in vitro against seven strains of Histoplasma capsulatum and in vivo in AKR and C57BL/6 murine models of histoplasmosis. UK 49,858 had a lower toxicity for AKR and C57BL/6 mice than amphotericin B did. The therapeutic index of UK 49,858 was 4.3 for AKR mice and 7.1 for C57BL/6; with amphotericin B it was 2 for both mouse strains. Given orally, UK 49,858 compared favorably with amphotericin B given intraperitoneally in either AKR or C57BL/6 mice infected with H. capsulatum.

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References

    1. Appl Environ Microbiol. 1981 Sep;42(3):560-3 - PubMed
    1. Antimicrob Agents Chemother. 1985 May;27(5):832-5 - PubMed
    1. Antimicrob Agents Chemother. 1985 Mar;27(3):302-5 - PubMed
    1. J Med Chem. 1983 Apr;26(4):611-3 - PubMed

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