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. 2018 Jul 12:2018:4039019.
doi: 10.1155/2018/4039019. eCollection 2018.

Development of a Traditional Chinese Medicine Syndrome-Specific Scale for Ulcerative Colitis: The Large Intestine Dampness-Heat Syndrome Questionnaire

Xin-Lin Chen  1 , Yi Wen  2 , Zu-Chun Wu  1 , Bei-Ping Zhang  3 , Zheng-Kun Hou  4 , Jun-Lin Xiao  5 , Man-Qing Lin  2 , Yue Hu  1 , Zhe-Li Wu  1 , Jie-Min Deng  1 , Feng-Bin Liu  4 , Tian-Wen Liu  3
Affiliations

Development of a Traditional Chinese Medicine Syndrome-Specific Scale for Ulcerative Colitis: The Large Intestine Dampness-Heat Syndrome Questionnaire

Xin-Lin Chen et al. Evid Based Complement Alternat Med. .

Abstract

The aim of this study was to develop and validate the large intestine dampness-heat syndrome questionnaire (LIDHSQ) for patients with ulcerative colitis (UC). The domains and items of the LIDHSQ were developed according to standard procedures, namely, construct definition, item generation, language testing, content validity, pilot study, and validation study. At first, a total of 20 items in 3 domains were generated based on literature review and expert consultation. After the item selection, the LIDHSQ contains 11 items in three domains: disease-related domain (diarrhoea, abdominal pain, bloody purulent stool, and mucus stool), heat domain (fever, dry mouth, red tongue, yellow fur, and anal burning), and dampness domain (greasy fur and defecation disorder). The Cronbach's alphas of all domains were greater than 0.6. All of the intraclass correlation coefficients were greater than 0.8. The LIDHSQ and domain scores of the patients with LIDHS were higher than those of the patients with other syndromes (P < 0.001). The area under the receiver operating characteristic curve of the LIDHSQ was 0.900, with a 95% confidence interval of 0.872-0.928. When the cut-off value of the LIDHSQ was ≥ 7, the sensitivity and specificity were 0.867 and 0.854, respectively. The LIDHSQ is valid and reliable for measuring LIDHS in UC patients with good diagnostic efficacy. We recommend the use of the LIDHSQ in Chinese UC patients.

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Figures

Figure 1
Figure 1
Four steps towards development of the procedure.
Figure 2
Figure 2
Structure diagram (standardized coefficient) of large intestine dampness-heat syndrome (items 1-11: diarrhoea, abdominal pain, mucus stool, bloody purulent stool, anal burning, red tongue, yellow fur, fever, dry mouth, greasy fur, and defecation disorder).
Figure 3
Figure 3
The ROC curve of large intestine dampness-heat syndrome.
See this image and copyright information in PMC

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