Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

M Matejcic¹, F Lesueur^{2

3

4

5}, C Biessy¹, A L Renault^{2

3

4

5}, N Mebirouk^{2

3

4

5}, S Yammine¹, P Keski-Rahkonen¹, K Li¹, B Hémon¹, E Weiderpass^{6

7

8

9}, V Rebours¹⁰, M C Boutron-Ruault^{11

12}, F Carbonnel^{11

12

13}, R Kaaks¹⁴, V Katzke¹⁴, T Kuhn¹⁴, H Boeing¹⁵, A Trichopoulou^{16

17}, D Palli¹⁸, C Agnoli¹⁹, S Panico²⁰, R Tumino²¹, C Sacerdote²², J R Quirós²³, E J Duell²⁴, M Porta²⁵, M J Sánchez^{26

27}, M D Chirlaque^{27

28

29}, A Barricarte^{27

30

31}, P Amiano^{9

27}, W Ye^{32

33}, P H Peeters^{34

35}, K T Khaw³⁶, A Perez-Cornago³⁷, T J Key³⁷, H B Bueno-de-Mesquita^{35

38}, E Riboli³⁵, P Vineis³⁹, I Romieu¹, M J Gunter¹, V Chajès¹

Affiliations

¹ International Agency for Research on Cancer, Lyon, France.
² Genetic Epidemiology of Cancer team, Inserm, U900, Paris, France.
³ Institut Curie, Paris, France.
⁴ PSL University, Paris, France.
⁵ Mines ParisTech, Fontainebleau, France.
⁶ Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.
⁷ Department of Community Medicine, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
⁸ Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway.
⁹ Public Health Division of Gipuzkoa, BioDonostia Research institute, San Sebastian, Spain.
¹⁰ Department of Gastroenterology and Pancreatology, Beaujon Hospital, University Paris 7, Clichy, France.
¹¹ INSERM, Centre for Research in Epidemiology and Population Health, U1018, Health across Generations Team, Institut Gustave Roussy, Villejuif, France.
¹² Université Paris Sud, UMRS, Villejuif, France.
¹³ Department of Gastroenterology, Bicêtre University Hospital, Assistance Publique des Hôpitaux de Paris, Le Kremlin Bicêtre, France.
¹⁴ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁵ Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
¹⁶ Hellenic Health Foundation, Athens, Greece.
¹⁷ WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
¹⁸ Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.
¹⁹ Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
²⁰ Clinical Medicine and Surgery Department, Università degli Studi di Napoli Federico II, Naples, Italy.
²¹ Cancer Registry and Histopathology Department, ASP, "Civic - M.P. Arezzo" Hospital, Ragusa, Italy.
²² Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital, University of Turin and Centre for Cancer Prevention (CPO), Turin, Italy.
²³ EPIC Asturias, Public Health Directorate, Asturias, Spain.
²⁴ Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
²⁵ Hospital del Mar Research Institute - IMIM, CIBER Epidemiología y Salud Pública (CIBERESP) and Universitat Autònoma de Barcelona, Barcelona, Spain.
²⁶ Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.
²⁷ CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
²⁸ Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
²⁹ Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain.
³⁰ Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
³¹ Navarra Public Health Institute, Pamplona, Spain.
³² Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
³³ The Medical Biobank at Umeå University, Umeå, Sweden.
³⁴ Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
³⁵ Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom.
³⁶ University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
³⁷ Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
³⁸ Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
³⁹ MRC-PHE Center for Environment and Health, School of Public Health, Imperial College, London, United Kingdom.

PMID: 30110135
DOI: 10.1002/ijc.31797

Free article

Multicenter Study

Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

M Matejcic et al. Int J Cancer. 2018.

Free article

. 2018 Nov 15;143(10):2437-2448.

doi: 10.1002/ijc.31797. Epub 2018 Sep 21.

Authors

Affiliations

¹ International Agency for Research on Cancer, Lyon, France.
² Genetic Epidemiology of Cancer team, Inserm, U900, Paris, France.
³ Institut Curie, Paris, France.
⁴ PSL University, Paris, France.
⁵ Mines ParisTech, Fontainebleau, France.
⁶ Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.
⁷ Department of Community Medicine, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
⁸ Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway.
⁹ Public Health Division of Gipuzkoa, BioDonostia Research institute, San Sebastian, Spain.
¹⁰ Department of Gastroenterology and Pancreatology, Beaujon Hospital, University Paris 7, Clichy, France.
¹¹ INSERM, Centre for Research in Epidemiology and Population Health, U1018, Health across Generations Team, Institut Gustave Roussy, Villejuif, France.
¹² Université Paris Sud, UMRS, Villejuif, France.
¹³ Department of Gastroenterology, Bicêtre University Hospital, Assistance Publique des Hôpitaux de Paris, Le Kremlin Bicêtre, France.
¹⁴ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁵ Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
¹⁶ Hellenic Health Foundation, Athens, Greece.
¹⁷ WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
¹⁸ Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.
¹⁹ Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
²⁰ Clinical Medicine and Surgery Department, Università degli Studi di Napoli Federico II, Naples, Italy.
²¹ Cancer Registry and Histopathology Department, ASP, "Civic - M.P. Arezzo" Hospital, Ragusa, Italy.
²² Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital, University of Turin and Centre for Cancer Prevention (CPO), Turin, Italy.
²³ EPIC Asturias, Public Health Directorate, Asturias, Spain.
²⁴ Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
²⁵ Hospital del Mar Research Institute - IMIM, CIBER Epidemiología y Salud Pública (CIBERESP) and Universitat Autònoma de Barcelona, Barcelona, Spain.
²⁶ Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.
²⁷ CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
²⁸ Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
²⁹ Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain.
³⁰ Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
³¹ Navarra Public Health Institute, Pamplona, Spain.
³² Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
³³ The Medical Biobank at Umeå University, Umeå, Sweden.
³⁴ Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
³⁵ Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom.
³⁶ University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
³⁷ Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
³⁸ Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
³⁹ MRC-PHE Center for Environment and Health, School of Public Health, Imperial College, London, United Kingdom.

PMID: 30110135
DOI: 10.1002/ijc.31797

Abstract

There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (OR_T3-T1 [odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41-0.98; p_trend = 0.036), n-3 polyunsaturated α-linolenic acid (OR_T3-T1 = 0.60; 95%CI = 0.39-0.92; p_trend = 0.02) and docosapentaenoic acid (OR_T3-T1 = 0.52; 95%CI = 0.32-0.85; p_trend = 0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (OR_T3-T1 = 3.00; 95%CI = 1.13-7.99; p_trend = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (OR_T3-T1 = 0.37; 95%CI = 0.17-0.81; p_trend = 0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (OR_T3-T1 = 3.40; 95%CI = 1.39-8.34; p_trend = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking.

Keywords: biomarkers; fatty acids; pancreatic cancer; plasma phospholipids; tobacco smoking.

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Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

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Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

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