Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jul 12:2018:5074923.
doi: 10.1155/2018/5074923. eCollection 2018.

High Prevalence of Sarcopenia in HIV-Infected Individuals

Patricia Echeverría  1   2 , Anna Bonjoch  1   2 , Jordi Puig  1 , Carla Estany  1 , Arelly Ornelas  3 , Bonaventura Clotet  1   2   4   5 , Eugenia Negredo  1   2   5
Affiliations

High Prevalence of Sarcopenia in HIV-Infected Individuals

Patricia Echeverría et al. Biomed Res Int. .

Abstract

Background: Sarcopenia is a geriatric syndrome that leads to a loss of functionality and mortality.

Methods: We assessed the prevalence of sarcopenia in HIV-infected patients attended in our HIV Unit who had at least two DXA scans from 2000 to 2016 (1,720 DXA scans from 860 individuals). Sarcopenia was determinate according to appendicular skeletal muscle mass index (ASM) calculated as the ratio between skeletal muscle mass index (SMI) by DXA and height2 (kg/m2). We stratified patients by gender and age (<40, 41-50, and >50 years) and according to the interval between DXAs (≤3, 3-7, 7-10, >10 years). The statistical analysis was performed using SPSS version 19.

Results: Median (IQR) age was 52 (47; 57) years, and 76% were male. The median (IQR) time with HIV infection was 8 (3; 15) years. The prevalence of sarcopenia was 25.7% (95% CI, 22.8-28.7), more prevalent in those aged >50 years (27.8%). Stratifying by gender, 43% of women aged >50 years presented sarcopenia compared with 8.8% of men. The frequency of sarcopenia increased from 37.6% to 49.4% when interval between DXA was 7-10 years (n=109), significantly higher in women than in men (p=0.016). In addition to the traditional risk factors, time with HIV infection was associated with sarcopenia [RR 1.780 (95% CI, 1.314-2.411), p=0.001].

Conclusion: The prevalence and progression of sarcopenia in HIV-infected patients were high, mainly among women. Further studies are necessary to assess the best approaches to prevent this condition and its consequences.

PubMed Disclaimer

References

    1. Deeks S. G., Phillips A. N. HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity. BMJ. 2009;338(3172) doi: 10.1136/bmj.a3172. - DOI - PubMed
    1. Deeks S. G. HIV infection, inflammation, immunosenescence, and aging. Annual Review of Medicine. 2011;62:141–155. doi: 10.1146/annurev-med-042909-093756. - DOI - PMC - PubMed
    1. Guaraldi G., Orlando G., Zona S., et al. Premature age-related comorbidities among HIV-infected persons compared with the general populationa. Clinical Infectious Diseases. 2011;53(11):1120–1126. doi: 10.1093/cid/cir627. - DOI - PubMed
    1. Pathai S., Bajillan H., Landay A. L., High K. P. Is HIV a model of accelerated or accentuated aging? The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2014;69(7):833–842. doi: 10.1093/gerona/glt168. - DOI - PMC - PubMed
    1. Kirk J. B., Goetz M. B. Human immunodeficiency virus in an aging population, a complication of success. Journal of the American Geriatrics Society. 2009;57(11):2129–2138. doi: 10.1111/j.1532-5415.2009.02494.x. - DOI - PubMed

LinkOut - more resources