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. 2018 Jul 19:2018:6381932.
doi: 10.1155/2018/6381932. eCollection 2018.

Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice

Ming Ru  1 , Hui Liu  1
Affiliations

Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice

Ming Ru et al. Biomed Res Int. .

Abstract

Objective: To explore the association between the acquisition process in the Y-maze and H-2 class II polymorphisms in mice.

Methods: Mice were trained for 5 consecutive days in the Y-maze. The value of the slope of the latent period was considered an indication for the acquisition process. A slope < 0 indicated learning during the training and a slope > 0 indicated no learning. The H-2 polymorphism was determined with PCR amplification, and the correlation between the alleles and the acquisition process was analyzed.

Results: The overall percentage of mice that learned was 46.1%. The percentage of mice that had learned with MudoEb5 (37.9%) was significantly lower than that of mice without MudoEb5 (61.1%; P < 0.05). The percentage of mice that had learned with MudoEb7 (26.1%) was significantly lower than that of mice without MudoEb7 (51.9%; P < 0.05).

Conclusions: The major histocompatibility complex (MHC) and other alleles may be involved in the acquisition process. There may be a biological basis for learning in mice.

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Figures

Figure 1
Figure 1
Y-maze apparatus and construction.
Figure 2
Figure 2
Comparative analysis of 3-, 4-, and 5-day slopes as learning indices.
Figure 3
Figure 3
PCR amplification products of MudoEb5 and MudoEb7.
See this image and copyright information in PMC

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